Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.
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Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapyRegulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticalsQuantitative proteomics reveals cellular targets of celastrolIdentification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAILDihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5Snake venom toxin from Vipera lebetina turanica induces apoptosis of colon cancer cells via upregulation of ROS- and JNK-mediated death receptor expressionNimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way.Tumor necrosis factor-α sensitizes breast cancer cells to natural products with proteasome-inhibitory activity leading to apoptosisCasticin potentiates TRAIL-induced apoptosis of gastric cancer cells through endoplasmic reticulum stress.Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer.A novel adenoviral vector carrying an all-in-one Tet-On system with an autoregulatory loop for tight, inducible transgene expression.Celastrol blocks interleukin-6 gene expression via downregulation of NF-κB in prostate carcinoma cellsRegulating TRAIL receptor-induced cell death at the membrane : a deadly discussionCelastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer.Degradable polyethylenimine derivate coupled to a bifunctional peptide R13 as a new gene-delivery vectorCardamonin sensitizes tumour cells to TRAIL through ROS- and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins.Targeting X-linked inhibitor of apoptosis protein inhibits pancreatic cancer cell growth through p-Akt depletion.Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition.Pomolic acid induces apoptosis in SK-OV-3 human ovarian adenocarcinoma cells through the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathwaysReal-time imaging of the dynamics of death receptors and therapeutics that overcome TRAIL resistance in tumors.The synergistic effects of traditional Chinese herbs and radiotherapy for cancer treatmentThe pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL‑induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells.Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors.Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-A new multicolor bioluminescence imaging platform to investigate NF-κB activity and apoptosis in human breast cancer cells.Celastrol increases osteosarcoma cell lysis by γδ T cells through up-regulation of death receptors.TRAIL combinations: The new 'trail' for cancer therapy (Review).Paradoxical action of growth factors: antiproliferative and proapoptotic signaling by HGF/c-MET.TRAIL-mediated signaling in prostate, bladder and renal cancer.Genetic determinants of oxidative stress-mediated sensitization of drug-resistant cancer cells.NutriTRAILomics in prostate cancer: time to have two strings to one's bow.Enzymatic biotransformation of terpenes as bioactive agents.Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression.Cytotoxic effect of celastrol alone or in combination with paclitaxel on anaplastic thyroid carcinoma cells.Natural Products as Mechanism-based Anticancer Agents: Sp Transcription Factors as Targets.Celastrol induces unfolded protein response-dependent cell death in head and neck cancer.Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells.
P2860
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P2860
Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Celastrol, a triterpene, enhan ...... regulation of death receptors.
@ast
Celastrol, a triterpene, enhan ...... regulation of death receptors.
@en
type
label
Celastrol, a triterpene, enhan ...... regulation of death receptors.
@ast
Celastrol, a triterpene, enhan ...... regulation of death receptors.
@en
prefLabel
Celastrol, a triterpene, enhan ...... regulation of death receptors.
@ast
Celastrol, a triterpene, enhan ...... regulation of death receptors.
@en
P2093
P2860
P356
P1476
Celastrol, a triterpene, enhan ...... regulation of death receptors.
@en
P2093
Bharat B Aggarwal
Bokyung Sung
Byoungduck Park
Vivek R Yadav
P2860
P304
11498-11507
P356
10.1074/JBC.M109.090209
P407
P577
2010-02-12T00:00:00Z