Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents - Wikidata - wikimedia - TriplyDB

Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents

Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents

http://www.wikidata.org/entity/Q33813010

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A structural biology perspective on NMDA receptor pharmacology and function Activation of NMDA receptors and the mechanism of inhibition by ifenprodil.Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy Structure and organization of heteromeric AMPA-type glutamate receptors X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism.Reduced curvature of ligand-binding domain free-energy surface underlies partial agonism at NMDA receptors.Glycine-dependent activation of NMDA receptors.Emerging structural insights into the function of ionotropic glutamate receptors.Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology.The Transmembrane Domain Mediates Tetramerization of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes.Disruption of S2-M4 linker coupling reveals novel subunit-specific contributions to N-methyl-d-aspartate receptor function and ethanol sensitivity.Protein Allostery and Conformational Dynamics.Computationally Discovered Potentiating Role of Glycans on NMDA Receptors.Retour aux sources: defining the structural basis of glutamate receptor activation.How to build the fastest receptor on earth.Dynamics of the Ligand Binding Domain Layer during AMPA Receptor Activation.Structural mechanisms of activation and desensitization in neurotransmitter-gated ion channels.Gating Motions and Stationary Gating Properties of Ionotropic Glutamate Receptors: Computation Meets Electrophysiology.Advancing NMDA Receptor Physiology by Integrating Multiple Approaches.NMDA receptors: linking physiological output to biophysical operation.Identification of critical functional determinants of kainate receptor modulation by auxiliary protein Neto2.Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM.Molecular Mechanoneurobiology: An Emerging Angle to Explore Neural Synaptic Functions.Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation.Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.Probing the Structural Dynamics of the NMDA Receptor Activation by Coarse-Grained Modeling.Heteromerization of ligand binding domains of N-methyl-D-aspartate receptor requires both coagonists, L-glutamate and glycine.Semiclosed Conformations of the Ligand-Binding Domains of NMDA Receptors during Stationary Gating.The structure-energy landscape of NMDA receptor gating.A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors.Mechanism-Based Mathematical Model for Gating of Ionotropic Glutamate Receptors.Structural Mechanisms of Gating in Ionotropic Glutamate Receptors.Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy.Novel Mode of Antagonist Binding in NMDA Receptors Revealed by the Crystal Structure of the GluN1-GluN2A Ligand-Binding Domain Complexed to NVP-AAM077.Structural modeling for the open state of an NMDA receptor.The LILI Motif of M3-S2 Linkers Is a Component of the NMDA Receptor Channel Gate.Surface Expression, Function, and Pharmacology of Disease-Associated Mutations in the Membrane Domain of the Human GluN2B Subunit.Activation and desensitization of ionotropic glutamate receptors by selectively triggering pre-existing motions.

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Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents

http://www.wikidata.org/entity/Q33813010

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2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents

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Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents

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Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents

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Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents

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prefLabel

Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents

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Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents

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Nature Neuroscience

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Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents

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Cameron Sweeney

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Lonnie P Wollmuth

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Rashek Kazi

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P2860

Currents through single glutamate receptor channels in outside-out patches from rat cerebellar granule cells

Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core

Structure and gating mechanism of the acetylcholine receptor pore

Structural basis for partial agonist action at ionotropic glutamate receptors

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

Conformational Analysis of NMDA Receptor GluN1, GluN2, and GluN3 Ligand-Binding Domains Reveals Subtype-Specific Characteristics

VMD: visual molecular dynamics

Protein structure prediction on the Web: a case study using the Phyre server

Scalable molecular dynamics with NAMD

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7

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Huan-Xiang Zhou

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2014-05-25T00:00:00Z

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