Inhibited cell growth and protein functional changes from an editing-defective tRNA synthetase.
about
From Prebiotics to Probiotics: The Evolution and Functions of tRNA ModificationsNon-Standard Genetic Codes Define New Concepts for Protein EngineeringThe Mechanism of Pre-transfer Editing in Yeast Mitochondrial Threonyl-tRNA SynthetaseDiscovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetaseSense codon emancipation for proteome-wide incorporation of noncanonical amino acids: rare isoleucine codon AUA as a target for genetic code expansionElongation Factor Tu Prevents Misediting of Gly-tRNA(Gly) Caused by the Design Behind the Chiral Proofreading Site of D-Aminoacyl-tRNA DeacylaseA genetic code alteration is a phenotype diversity generator in the human pathogen Candida albicans.Severe oxidative stress induces protein mistranslation through impairment of an aminoacyl-tRNA synthetase editing site.Mistranslation can enhance fitness through purging of deleterious mutations.Oxidation of cellular amino acid pools leads to cytotoxic mistranslation of the genetic codeMistakes in translation don't translate into terminationIn vivo identification of essential nucleotides in tRNALeu to its functions by using a constructed yeast tRNALeu knockout strain.Protein aggregation caused by aminoglycoside action is prevented by a hydrogen peroxide scavenger.Rapid evolution of diminished transformability in Acinetobacter baylyi.Homologous trans-editing factors with broad tRNA specificity prevent mistranslation caused by serine/threonine misactivation.Uneven spread of cis- and trans-editing aminoacyl-tRNA synthetase domains within translational compartments of P. falciparum.An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS responseGenetic code ambiguity confers a selective advantage on Acinetobacter baylyi.Phenylalanyl-tRNA synthetase editing defects result in efficient mistranslation of phenylalanine codons as tyrosine.Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.Mitochondrial deafness alleles confer misreading of the genetic codeSelection of tRNA charging quality control mechanisms that increase mistranslation of the genetic code.Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents.Transcriptional mutagenesis: causes and involvement in tumour development.The Yin and Yang of tRNA: proper binding of acceptor end determines the catalytic balance of editing and aminoacylation.Comprehensive analysis of phosphorylated proteins of Escherichia coli ribosomes.The evolutionary consequences of erroneous protein synthesis.Quality Control by Isoleucyl-tRNA Synthetase of Bacillus subtilis Is Required for Efficient Sporulation.Transfer RNA: a dancer between charging and mis-charging for protein biosynthesis.Function and origin of mistranslation in distinct cellular contexts.Rewiring protein synthesis: From natural to synthetic amino acids.A naturally occurring nonapeptide functionally compensates for the CP1 domain of leucyl-tRNA synthetase to modulate aminoacylation activity.Mechanism of oxidant-induced mistranslation by threonyl-tRNA synthetase.Evolving Mistranslating tRNAs Through a Phenotypically Ambivalent Intermediate in Saccharomyces cerevisiae.Silencing of Essential Genes within a Highly Coordinated Operon in Escherichia coli.Role of D-aminoacyl-tRNA deacylase beyond chiral proofreading as a cellular defense against glycine mischarging by AlaRS.Natural homolog of tRNA synthetase editing domain rescues conditional lethality caused by mistranslation.Interdomain communication modulates the tRNA-dependent pre-transfer editing of leucyl-tRNA synthetase.Fluorothreonyl-tRNA deacylase prevents mistranslation in the organofluorine producer Streptomyces cattleya.Unique residues crucial for optimal editing in yeast cytoplasmic Leucyl-tRNA synthetase are revealed by using a novel knockout yeast strain.
P2860
Q26764834-D3FA2EDD-AE7B-4373-9491-7B3B6153A9E0Q26822920-54BB9931-3FA8-4AE5-9CA5-1DEE4A11542FQ27670681-E16AAA46-BA1C-433A-BC8E-379C2CBAAD7FQ27679720-978B507E-65E1-4D3F-B427-6BC076139719Q28305963-96334403-B809-453C-9073-3C639FCCB138Q28552401-2025BB1C-7770-4368-948C-7DA37D851AE8Q33301346-E7A24D05-61E9-4DD6-88EB-7CF1CBEA0D79Q33733028-9A5387FA-3212-4124-BEDB-E03754BC74A0Q33754318-A77EB857-0E01-44CD-A1E7-8A15F8DFFF07Q33789736-5B543DC8-8832-46CF-BA4B-875A20A2BC76Q33818566-328C621E-ECF5-43C2-BD11-E441BDF9F019Q34392129-B8519D9A-F4B7-4DE0-B309-A59EA0AC7C4FQ34466043-0AF8817C-0BE3-4A26-9F74-BC786E81A669Q35220658-F0080E9A-9465-4BC8-A899-7700BC65A24BQ35616247-8E9C47D4-98E0-4C78-9602-9B2DA4AAF6F1Q35619612-03C8B782-4F93-408A-809D-8B891B8FF483Q35629407-07BCDD1F-0689-4EB7-B9F3-19D23B2BF5E7Q35949465-69073BF8-A52D-4E70-8E84-765B7F719D88Q36088329-C826CF1C-7F2F-4580-AEAF-8967796EC1A7Q36320180-B36C30A9-4F8C-4602-AFF5-939C2531985DQ36491293-C3AD6D9D-276E-477E-BD8A-892319DA0233Q36559252-B9B6F7C8-A9DC-4F83-8287-31D9345CC620Q36802598-23C4634A-EF6F-41D0-8BFF-27DD6366EBF7Q36861991-DE551828-765E-4E97-95BB-109345C2F37FQ36878510-51E9D958-C1B8-4207-8B5D-DCEBBFC0311AQ37384545-15082331-E91D-4B23-B905-D6FFB7FB97C6Q37393307-95560319-4967-41C1-A73B-4D707CD765F4Q37615177-DE7DCBD8-4ED6-4831-86E4-930E6C34F487Q38132082-61EBE41A-C872-4DE0-B494-3CDF880FD758Q39079449-BE1015C8-8D70-4A02-9644-854514DBEB65Q39092037-29280874-922B-4BB9-BC93-999168ED43AEQ39658077-BDC8AFE7-E7DD-49D3-9BD1-D94F9B37B78DQ40164475-7BB25FB5-54F6-45F9-AB0F-ADA60433E34BQ41445289-48DF12E9-8F34-428C-BBEE-8288A9A8195EQ41988721-D8FEBB37-A3C4-49FD-8D59-351A3535D724Q42290156-DF2F0A5D-29FD-402F-96AC-F41B9893EBBAQ43251134-5F7FFDA8-BD12-4415-BF50-307A66D7BB6FQ44478323-AC9E96BE-156B-4D1B-9984-9D8FE23B2890Q46113351-06D946F0-22E7-4F56-BD0B-894DD8EDDD20Q46542921-84B505C1-B3E2-4E84-B182-2BC30996273A
P2860
Inhibited cell growth and protein functional changes from an editing-defective tRNA synthetase.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Inhibited cell growth and prot ...... ing-defective tRNA synthetase.
@ast
Inhibited cell growth and prot ...... ing-defective tRNA synthetase.
@en
type
label
Inhibited cell growth and prot ...... ing-defective tRNA synthetase.
@ast
Inhibited cell growth and prot ...... ing-defective tRNA synthetase.
@en
prefLabel
Inhibited cell growth and prot ...... ing-defective tRNA synthetase.
@ast
Inhibited cell growth and prot ...... ing-defective tRNA synthetase.
@en
P2860
P356
P1476
Inhibited cell growth and prot ...... ing-defective tRNA synthetase.
@en
P2093
Jamie M Bacher
Paul R Schimmel
P2860
P304
P356
10.1073/PNAS.0409064102
P407
P577
2005-01-12T00:00:00Z