Neuronal nicotinic acetylcholine receptors as novel drug targets.
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Chemistry and pharmacology of nicotinic ligands based on 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for possible use in depressionStructural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotineEstablishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural NootropicEscherichia coli Protein Expression System for Acetylcholine Binding Proteins (AChBPs)Marine Toxins Targeting Ion ChannelsNegative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors.A New and Efficient Approach to the Synthesis of Nicotine and Anabasine Analogues.Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy.The analgesic and toxic effects of nornicotine enantiomers alone and in interaction with morphine in rodent models of acute and persistent pain.Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-(substituted phenyl)epibatidine analogues. Nicotinic partial agonists.A gating mechanism proposed from a simulation of a human alpha7 nicotinic acetylcholine receptorThe influence of a chronic adolescent nicotine exposure on ethanol withdrawal severity during adulthood in C3H mice.Improved Syntheses of Precursors for PET Radioligands [F]XTRA and [F]AZAN.Chemistry and pharmacological characterization of novel nitrogen analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) as α4β2-nicotinic acetylcholine receptor-selective partial agonists.α7 Nicotinic Receptor Agonists: Potential Therapeutic Drugs for Treatment of Cognitive Impairments in Schizophrenia and Alzheimer's Disease.Cloning and spatiotemporal expression of zebrafish neuronal nicotinic acetylcholine receptor alpha 6 and alpha 4 subunit RNAs.Membrane potential fluorescence: a rapid and highly sensitive assay for nicotinic receptor channel function.Novel information on the non-neuronal cholinergic system in orthopedics provides new possible treatment strategies for inflammatory and degenerative diseasesCharacterization of a novel alpha4/4-conotoxin, Qc1.2, from vermivorous Conus quercinus.Structure-activity relationship studies of sulfonylpiperazine analogues as novel negative allosteric modulators of human neuronal nicotinic receptors.3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human α4β2 neuronal nicotinic acetylcholine receptors.Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs.Quantitative Molecular Imaging of Neuronal Nicotinic Acetylcholine Receptors in the Human Brain with A-85380 Radiotracers.The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation.Effects of nicotine and mecamylamine on cognition in rhesus monkeys.Defining the putative inhibitory site for a selective negative allosteric modulator of human α4β2 neuronal nicotinic receptorsSynthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity.N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors.A practical and efficient route for the highly enantioselective synthesis of mexiletine analogues and novel beta-thiophenoxy and pyridyl ethers.Highly enantioselective borane reduction of heteroaryl and heterocyclic ketoxime ethers catalyzed by novel spiroborate ester derived from diphenylvalinol: application to the synthesis of nicotine analogues.Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomographyMolecular modeling of mono- and bis-quaternary ammonium salts as ligands at the alpha4beta2 nicotinic acetylcholine receptor subtype using nonlinear techniques.Interaction of bupropion with muscle-type nicotinic acetylcholine receptors in different conformational states.From smoking to lung cancer: the CHRNA5/A3/B4 connection.Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted pyridinyl)-7-deschloroepibatidine analogues.A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus).Acetylcholine promotes binding of α-conotoxin MII at α3 β2 nicotinic acetylcholine receptors.Insights into nicotinic receptor signaling in nicotine addiction: Implications for prevention and treatment.In vivo pharmacological profile of substituted (3-pyridyl)-2-phenylisoxazolidine analogues of nicotine as novel antinociceptives.Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor.
P2860
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P2860
Neuronal nicotinic acetylcholine receptors as novel drug targets.
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2000 nî lūn-bûn
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2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2000 թվականի փետրվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Neuronal nicotinic acetylcholine receptors as novel drug targets.
@ast
Neuronal nicotinic acetylcholine receptors as novel drug targets.
@en
type
label
Neuronal nicotinic acetylcholine receptors as novel drug targets.
@ast
Neuronal nicotinic acetylcholine receptors as novel drug targets.
@en
prefLabel
Neuronal nicotinic acetylcholine receptors as novel drug targets.
@ast
Neuronal nicotinic acetylcholine receptors as novel drug targets.
@en
P1476
Neuronal nicotinic acetylcholine receptors as novel drug targets.
@en
P2093
P304
P407
P577
2000-02-01T00:00:00Z