The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation
about
The cholesterol-dependent cytolysin signature motif: a critical element in the allosteric pathway that couples membrane binding to pore assemblyCholesterol-dependent cytolysins, a family of versatile pore-forming toxinsInerolysin, a cholesterol-dependent cytolysin produced by Lactobacillus inersCharacterization of a streptococcal cholesterol-dependent cytolysin with a lewis y and b specific lectin domainObstructing toxin pathways by targeted pore blockageConformational changes during pore formation by the perforin-related protein pleurotolysinA new model for pore formation by cholesterol-dependent cytolysinspH dependence of listeriolysin O aggregation and pore-forming abilityCryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin.An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin.Perfringolysin O structure and mechanism of pore formation as a paradigm for cholesterol-dependent cytolysinsDisulfide-bond scanning reveals assembly state and β-strand tilt angle of the PFO β-barrel.Membrane assembly of the cholesterol-dependent cytolysin pore complex.The MACPF/CDC family of pore-forming toxins.Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysinsOnly two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface.Efficient isolation of Pseudomonas aeruginosa type III secretion translocators and assembly of heteromeric transmembrane pores in model membranes.Revealing the topography of cellular membrane domains by combined atomic force microscopy/fluorescence imagingPerforin: structure, function, and role in human immunopathology.Conformational changes that effect oligomerization and initiate pore formation are triggered throughout perfringolysin O upon binding to cholesterol.Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions.Plasma membrane-associated proteins are clustered into islands attached to the cytoskeletonPerfringolysin O: The Underrated Clostridium perfringens Toxin?Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins.Listeriolysin O: a key protein of Listeria monocytogenes with multiple functions.Altering hydrophobic sequence lengths shows that hydrophobic mismatch controls affinity for ordered lipid domains (rafts) in the multitransmembrane strand protein perfringolysin O.Specific protein-membrane contacts are required for prepore and pore assembly by a cholesterol-dependent cytolysinTransmembrane protein (perfringolysin o) association with ordered membrane domains (rafts) depends upon the raft-associating properties of protein-bound sterol.Listeriolysin O as a strong immunogenic molecule for the development of new anti-tumor vaccinesThe influence of natural lipid asymmetry upon the conformation of a membrane-inserted protein (perfringolysin O)Alternate pleckstrin homology domain orientations regulate dynamin-catalyzed membrane fission.Toxins from bacteria.Real-time visualization of perforin nanopore assembly.Quenching of triplet state fluorophores for studying diffusion-mediated reactions in lipid membranes.Membrane protein TM segments are retained at the translocon during integration until the nascent chain cues FRET-detected release into bulk lipid.Engineered covalent leucotoxin heterodimers form functional pores: insights into S-F interactions.Switch-like responses of two cholesterol sensors do not require protein oligomerization in membranes.Real-time detection reveals that effectors couple dynamin's GTP-dependent conformational changes to the membrane.
P2860
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P2860
The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation
description
2005 nî lūn-bûn
@nan
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The domains of a cholesterol-d ...... angement during pore formation
@ast
The domains of a cholesterol-d ...... angement during pore formation
@en
type
label
The domains of a cholesterol-d ...... angement during pore formation
@ast
The domains of a cholesterol-d ...... angement during pore formation
@en
prefLabel
The domains of a cholesterol-d ...... angement during pore formation
@ast
The domains of a cholesterol-d ...... angement during pore formation
@en
P2860
P356
P1476
The domains of a cholesterol-d ...... angement during pore formation
@en
P2093
Arthur E Johnson
Rodney K Tweten
P2860
P304
P356
10.1073/PNAS.0500556102
P407
P577
2005-05-06T00:00:00Z