Large induces functional glycans in an O-mannosylation dependent manner and targets GlcNAc terminals on alpha-dystroglycan - Wikidata - wikimedia - TriplyDB

Large induces functional glycans in an O-mannosylation dependent manner and targets GlcNAc terminals on alpha-dystroglycan

Large induces functional glycans in an O-mannosylation dependent manner and targets GlcNAc terminals on alpha-dystroglycan

http://www.wikidata.org/entity/Q33828666

about

LARGE2 generates the same xylose- and glucuronic acid-containing glycan structures as LARGE Adeno-associated virus-mediated overexpression of LARGE rescues α-dystroglycan function in dystrophic mice with mutations in the fukutin-related protein.Differential glycosylation of α-dystroglycan and proteins other than α-dystroglycan by like-glycosyltransferase High throughput screening for compounds that alter muscle cell glycosylation identifies new role for N-glycans in regulating sarcolemmal protein abundance and laminin binding Identification of antithrombin-modulating genes. Role of LARGE, a gene encoding a bifunctional glycosyltransferase, in the secretion of proteins?Identification of mutations in TMEM5 and ISPD as a cause of severe cobblestone lissencephaly Laminins in basement membrane assembly Missense mutations in β-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) cause Walker-Warburg syndrome.LARGE2-dependent glycosylation confers laminin-binding ability on proteoglycans.Mammalian O-mannosylation pathway: glycan structures, enzymes, and protein substrates.Second international workshop for glycosylation defects in muscular dystrophies, 11-12 November, 2010, Charlotte, USA.

P2860

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P2860

Large induces functional glycans in an O-mannosylation dependent manner and targets GlcNAc terminals on alpha-dystroglycan

http://www.wikidata.org/entity/Q33828666

description

2011 nî lūn-bûn

@nan

2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Large induces functional glyca ...... erminals on alpha-dystroglycan

@ast

Large induces functional glyca ...... erminals on alpha-dystroglycan

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type

label

Large induces functional glyca ...... erminals on alpha-dystroglycan

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Large induces functional glyca ...... erminals on alpha-dystroglycan

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Large induces functional glyca ...... erminals on alpha-dystroglycan

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Large induces functional glyca ...... erminals on alpha-dystroglycan

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Large induces functional glyca ...... erminals on alpha-dystroglycan

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Qilong Lu

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Xiaohua Wu

http://www.w3.org/2001/XMLSchema#string

Yihong Hu

http://www.w3.org/2001/XMLSchema#string

Zhi-fang Li

http://www.w3.org/2001/XMLSchema#string

P2860

The human LARGE gene from 22q12.3-q13.1 is a new, distinct member of the glycosyltransferase gene family

Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1

Demonstration of mammalian protein O-mannosyltransferase activity: coexpression of POMT1 and POMT2 required for enzymatic activity

Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase

A role of fukutin, a gene responsible for Fukuyama type congenital muscular dystrophy, in cancer cells: a possible role to suppress cell proliferation

An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy

Mutations in the fukutin-related protein gene (FKRP) cause a form of congenital muscular dystrophy with secondary laminin alpha2 deficiency and abnormal glycosylation of alpha-dystroglycan.

Mutations in the O-mannosyltransferase gene POMT1 give rise to the severe neuronal migration disorder Walker-Warburg syndrome

POMT2 mutations cause alpha-dystroglycan hypoglycosylation and Walker-Warburg syndrome

Mutations in the human LARGE gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan

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