Identification of receptor-binding residues in the inflammatory complement protein C5a by site-directed mutagenesis - Wikidata - wikimedia - TriplyDB

Identification of receptor-binding residues in the inflammatory complement protein C5a by site-directed mutagenesis

Identification of receptor-binding residues in the inflammatory complement protein C5a by site-directed mutagenesis

http://www.wikidata.org/entity/Q33829523

about

Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus Identification of receptor-binding sites of monocyte chemotactic S19 ribosomal protein dimer Structural and functional characterization of human and murine C5a anaphylatoxins Structural definition of the C5a C terminus by two-dimensional nuclear magnetic resonance spectroscopy C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism An activation switch in the ligand binding pocket of the C5a receptor.Cloning and functional expression of the canine anaphylatoxin C5a receptor. Evidence for high interspecies variability.Random mutagenesis of the complement factor 5a (C5a) receptor N terminus provides a structural constraint for C5a docking.Structure of the complement factor 5a receptor-ligand complex studied by disulfide trapping and molecular modeling.Restricted ability of group B streptococcal C5a-ase to inactivate C5a prepared from different animal species.Surface proteins of Streptococcus agalactiae and related proteins in other bacterial pathogens.Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors.Pharmacological characterization of antagonists of the C5a receptor Site-specific mutations in the N-terminal region of human C5a that affect interactions of C5a with the neutrophil C5a receptor.Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor.The role of complement, C5a and its receptors in sepsis and multiorgan dysfunction syndrome.Cell-free synthesis of isotopically labelled peptide ligands for the functional characterization of G protein-coupled receptors.Enhancement of in vivo and in vitro immune functions by a conformationally biased, response-selective agonist of human C5a: implications for a novel adjuvant in vaccine design.Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.Structural mechanisms of constitutive activation in the C5a receptors with mutations in the extracellular loops: molecular modeling study.Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site.Allosterism in human complement component 5a ((h)C5a): a damper of C5a receptor (C5aR) signaling.Identification of ligand effector binding sites in transmembrane regions of the human G protein-coupled C3a receptor.Probing the "message:address" sites for chemoattractant binding to the C5a receptor. Mutagenesis of hydrophilic and proline residues within the transmembrane segments.Mutation of glutamate 199 of the human C5a receptor defines a binding site for ligand distinct from the receptor N terminus.Complement C5a receptor assay for high throughput screening.Solution structure of a unique C5a semi-synthetic antagonist: implications in receptor binding.Structural models for the complex of chemotaxis inhibitory protein of Staphylococcus aureus with the C5a receptor.A recombinant hybrid anaphylatoxin with dual C3a/C5a activity.The pharmacophore of the human C5a anaphylatoxin.Pivotal Advance: Interconversion between pure chemotactic ligands and chemoattractant/secretagogue ligands of neutrophil C5a receptor by a single amino acid substitution.Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor.Identification of novel inhibitors of the translationally controlled tumor protein (TCTP): insights from molecular dynamics.The Model Structures of the Complement Component 5a Receptor (C5aR) Bound to the Native and Engineered hC5a.Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors.The influence of Lys68 in decepeptide agonists of C5a on C5a receptor binding, activation and selectivity.

P2860

Q24529541-DED8BA03-4E56-40DB-BBCE-55CB54614BCC Q24685662-661DA244-E18B-4534-A1FE-6E9C736DF6A3 Q27684270-71F24423-8AAA-4CB7-A09B-AF0BF3D188CB Q27739356-02C85A3D-37A5-4E0F-B6DE-5FCDBF18E9B6 Q28211612-4E47B2C1-C551-4FAE-85D2-BBBD0AD2C3E5 Q28268382-88C90738-842C-4465-A415-C278D97AEE87 Q28571336-612D54A1-3C90-4D7F-8A84-94709E77DE83 Q31524077-0FFE5FBF-0AAE-4ED0-9D65-91F223761E0E Q33196760-9C01EE86-44AD-4488-8D19-B28E4652B0A3 Q33259490-F7A8ABE4-55B0-46AB-AD36-AE9FEB99B726 Q33314698-AD2533A2-FD4F-4E39-973C-CC14D69F8CEF Q33620267-72879CA6-A550-44B1-BEFB-47702F56FC89 Q33719415-A74476B9-EF93-4616-8D25-8BEE6FCDC676 Q35034275-CB60C8BC-7BAC-4005-846E-4DF0C30A4DA5 Q35041753-E2D1CE7F-2202-4925-8F56-1FD035E07A62 Q36278194-33AA8FEC-E361-40D5-8367-FE7EAFFE6E2E Q36369323-9B7DC9A2-7564-4C01-ACF7-E8BEB509A11D Q36533660-9D94A699-5532-42CD-818C-578256EECEFA Q36694399-663E8460-4556-461D-BDCF-F345DA48D3FB Q37461020-1554E0FB-777D-496A-814A-845B0515AE74 Q38299564-B3CBD8A8-D592-4FC0-AFDE-D86E57A66D1F Q39864197-BBA6569A-040A-46BC-841D-02D4DEFC2CA3 Q40468378-12AF9C2F-6328-40CA-B43E-20F14B342159 Q40695140-A809F36D-6D27-44B0-A2F1-1444F00CCC06 Q40912578-D4573242-A9D7-4E89-8D35-37C0411967B7 Q41323110-5A61C535-A3E0-49A1-9146-ABEB29820450 Q41325958-2A22A319-A126-4AEA-BC8A-F7939FD49D3D Q41699759-C069CF30-A4BC-4F22-AF7B-C007892D0EC7 Q41777734-4185DFD4-27A3-40F1-89DD-7A29578B0621 Q41974458-BBFB100C-BE43-4586-8F90-EBAEDBB5D1E0 Q42267186-8A65091B-B67C-41F4-AA26-37D59C36EEC9 Q42844326-EF3C3352-3193-464B-9B61-C997BAC3ED7B Q43188289-7955AD72-5595-4E30-BE84-1928BEC7B982 Q45154618-E3132F39-F460-45CA-9631-B9F8EF5ED3BA Q48048743-7435EE69-6C89-4D4C-BA4E-6DC88476FC9A Q49475934-8F39163E-74D6-42B1-BF6E-524E784C0C76 Q50277552-D1BC69ED-2F42-454C-9211-0F7201FE5E43 Q52911287-7871F78B-4202-45B5-BA2A-1F4B8804D447

P2860

Identification of receptor-binding residues in the inflammatory complement protein C5a by site-directed mutagenesis

http://www.wikidata.org/entity/Q33829523

description

1989 nî lūn-bûn

@nan

1989 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

1989 թվականի հունվարին հրատարակված գիտական հոդված

@hy

1989年の論文

@ja

1989年論文

@yue

1989年論文

@zh-hant

1989年論文

@zh-hk

1989年論文

@zh-mo

1989年論文

@zh-tw

1989年论文

@wuu

name

Identification of receptor-bin ...... a by site-directed mutagenesis

@ast

Identification of receptor-bin ...... a by site-directed mutagenesis

@en

type

label

Identification of receptor-bin ...... a by site-directed mutagenesis

@ast

Identification of receptor-bin ...... a by site-directed mutagenesis

@en

prefLabel

Identification of receptor-bin ...... a by site-directed mutagenesis

@ast

Identification of receptor-bin ...... a by site-directed mutagenesis

@en

P1433

Q33829523-3FF91CF8-2FB2-4DB7-9A45-4DF371491BD2

P1476

Q33829523-3EA164AB-F0FF-4854-9118-D08FA18390DA

P2093

Q33829523-16543999-698A-4B1E-9B26-AEEA8817D104

Q33829523-1B98BB46-435D-4382-9697-0ECBD1526EB5

Q33829523-1EB5E365-D4CC-4FAA-A3A2-011D487579B1

Q33829523-2D84534C-5059-49DF-9681-3A8F7AB5BCC7

Q33829523-3624972B-E5A4-4878-B699-739C92AC7BA7

Q33829523-4935521A-DD29-4807-9EFD-6038DC4609FE

Q33829523-621B4DB1-396B-4F5F-86C3-264C3BE90C53

Q33829523-75E63648-08E9-4828-8F80-A90E9BBB4119

Q33829523-7EECC06F-FA10-489F-8585-26A221B2BB50

Q33829523-80A0704C-AACD-44C2-9E76-B7102AC8572A

P2860

Q33829523-033C5297-7594-4CF0-A063-5FB16F82AC11

Q33829523-03AE6F32-BF64-40A2-A3E9-C18159E50122

Q33829523-12B4AB49-941D-447A-838B-8EA1D6E26A8B

Q33829523-1374F029-A15D-4088-A43E-754D8AF5C799

Q33829523-29608487-F703-4937-92F8-AE644F99324F

Q33829523-2C7D4B0D-ABEB-4659-97B3-E9E7F416432C

Q33829523-3A33D1F1-1256-4267-AF78-0D6A23F296E3

Q33829523-41A53D4F-D0FB-47EE-9C9A-B1401B46E1D2

Q33829523-4B1C888E-F043-41F6-892D-8803582E5489

Q33829523-4FC0DBF3-81F2-4AE0-B8B9-33BAFC96FC31

P304

Q33829523-0AF6249D-04CC-4038-8F26-657FF779E83A

P31

Q33829523-E01A9422-11AE-4100-B9A8-65B695A071C4

P356

Q33829523-87CDC461-766E-4F6B-9AA1-D530BF97B44A

P407

Q33829523-36EB6A3D-712B-47F0-8C4B-7EED986A56D2

P433

Q33829523-362C3F63-856C-4802-9854-7AAD91B760A1

P478

Q33829523-8FCC5A5F-6B7F-480B-B6AE-AAE6301B1A2E

P577

Q33829523-6C7E256B-AA32-4FD0-B011-8905F9B02EF6

P5875

Q33829523-774F096B-AE9C-4AF5-BA69-1D957EBB4F8D

P698

Q33829523-C1D67840-13E9-4845-8759-163843AF2214

P921

Q33829523-99A5F10B-D8E7-4852-8A76-B87D32D7154D

P932

Q33829523-ADD395BD-3645-4F22-A6D4-F43BCEEE81C2

P356

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Identification of receptor-bin ...... a by site-directed mutagenesis

@en

P2093

Conway RG

http://www.w3.org/2001/XMLSchema#string

Edalji RP

http://www.w3.org/2001/XMLSchema#string

Fayer L

http://www.w3.org/2001/XMLSchema#string

Fey TA

http://www.w3.org/2001/XMLSchema#string

Krause RA

http://www.w3.org/2001/XMLSchema#string

Mandecki W

http://www.w3.org/2001/XMLSchema#string

Miller L

http://www.w3.org/2001/XMLSchema#string

Mollison KW

http://www.w3.org/2001/XMLSchema#string

Shallcross MA

http://www.w3.org/2001/XMLSchema#string

Zuiderweg ER

http://www.w3.org/2001/XMLSchema#string

P2860

Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin. Polypeptide sequence determination and assignment of the oligosaccharide attachment site in C5a

Sequence-specific assignments in the 1H NMR spectrum of the human inflammatory protein C5a

Secondary structure of complement component C3a anaphylatoxin in solution as determined by NMR spectroscopy: differences between crystal and solution conformations.

C5a fragment of bovine complement. Purification, bioassays, amino-acid sequence and other structural studies.

Primary structure of the fifth component of murine complement.

Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.

Demonstration of a specific receptor for human C5a anaphylatoxin on murine macrophages

Oligonucleotide-directed double-strand break repair in plasmids of Escherichia coli: a method for site-specific mutagenesis.

Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes.

Chemical synthesis of a gene encoding the human complement fragment C5a and its expression in Escherichia coli.

P304

292-296

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.86.1.292

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

86

http://www.w3.org/2001/XMLSchema#string

P577

1989-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

20513317

http://www.w3.org/2001/XMLSchema#string

P698

2643101

http://www.w3.org/2001/XMLSchema#string

P921

P932

286450

http://www.w3.org/2001/XMLSchema#string