Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues.
about
Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoproteinPro42 and Val45 of staphylokinase modulate intermolecular interactions of His43-Tyr44 pair and specificity of staphylokinase-plasmin activator complexDimer formation drives the activation of the cell death protease caspase 9Crystal structure of the native plasminogen reveals an activation-resistant compact conformationFunctional Regulation of the Plasma Protein Histidine-Rich Glycoprotein by Zn2+ in Settings of Tissue InjuryEffect of Fagonia Arabica (Dhamasa) on in vitro thrombolysis.Epic Immune Battles of History: Neutrophils vs. Staphylococcus aureus.A bacterial pathogen co-opts host plasmin to resist killing by cathelicidin antimicrobial peptidesEffects of organic extracts of six Bangladeshi plants on in vitro thrombolysis and cytotoxicityRNAi-mediated downregulation of urokinase plasminogen activator and its receptor in human meningioma cells inhibits tumor invasion and growth.Development of thrombolytic therapy for stroke: a perspective.Coevolutionary patterns in plasminogen activationEffects of organic extracts and their different fractions of five Bangladeshi plants on in vitro thrombolysisAntibiotic modulation of the plasminogen binding ability of viridans group streptococci.Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models.Pathogen activators of plasminogenActivity Regulation by Fibrinogen and Fibrin of Streptokinase from Streptococcus Pyogenes.Bacterial plasminogen receptors utilize host plasminogen system for effective invasion and dissemination.Staphylococcus aureus exploits cathelicidin antimicrobial peptides produced during early pneumonia to promote staphylokinase-dependent fibrinolysis.Defining the structural basis of human plasminogen binding by streptococcal surface enolaseHuman pathogens utilize host extracellular matrix proteins laminin and collagen for adhesion and invasion of the host.Involvement of a nine-residue loop of streptokinase in the generation of macromolecular substrate specificity by the activator complex through interaction with substrate kringle domains.Bacterial screening of platelet components by National Health Service Blood and Transplant, an effective risk reduction measure.Role of the C-terminal lysine residues of streptococcal surface enolase in Glu- and Lys-plasminogen-binding activities of group A streptococci.Molecular Interactions of Human Plasminogen with Fibronectin-binding Protein B (FnBPB), a Fibrinogen/Fibronectin-binding Protein from Staphylococcus aureus.Streptococcus pyogenes triggers activation of the human contact system by streptokinase.Cross-inhibition of pathogenic agents and the host proteins they exploit.Over-expression and purification of active serine proteases and their variants from Escherichia coli inclusion bodies.Site-restricted plasminogen activation mediated by group A streptococcal streptokinase variants.Identification through combinatorial random and rational mutagenesis of a substrate-interacting exosite in the gamma domain of streptokinase.Function of the 90-loop (Thr90-Glu100) region of staphylokinase in plasminogen activation probed through site-directed mutagenesis and loop deletion.Localization of epitopes for monoclonal antibodies to urokinase-type plasminogen activator: relationship between epitope localization and effects of antibodies on molecular interactions of the enzyme.Resolution of conformational activation in the kinetic mechanism of plasminogen activation by streptokinase.Chimerism reveals a role for the streptokinase Beta -domain in nonproteolytic active site formation, substrate, and inhibitor interactions.alpha Domain deletion converts streptokinase into a fibrin-dependent plasminogen activator through mechanisms akin to staphylokinase and tissue plasminogen activator.The mechanism of a bacterial plasminogen activator intermediate between streptokinase and staphylokinase.Domain truncation studies reveal that the streptokinase-plasmin activator complex utilizes long range protein-protein interactions with macromolecular substrate to maximize catalytic turnover.Impact of Bradykinin Generation During Thrombolysis in Ischemic Stroke
P2860
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P2860
Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues.
description
2000 nî lūn-bûn
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2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2000 թվականի փետրվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年學術文章
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name
Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues.
@ast
Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues.
@en
type
label
Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues.
@ast
Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues.
@en
prefLabel
Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues.
@ast
Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues.
@en
P2093
P1476
Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues.
@en
P2093
P356
10.1016/S0968-0004(99)01521-2
P577
2000-02-01T00:00:00Z