Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis
about
Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasisMurine mutants in the study of systemic iron metabolism and its disorders: an update on recent advancesThe role of TMPRSS6/matriptase-2 in iron regulation and anemiaModulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approachesHepcidin and iron regulation, 10 years later.β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapiesSuppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 proteinPathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivoPharmacotherapy for comorbidities in chronic heart failure: a focus on hematinic deficiencies, diabetes mellitus and hyperkalemia.N-glycosylation is required for matriptase-2 autoactivation and ectodomain sheddingEffect of iron overload and iron deficiency on liver hemojuvelin proteinNovel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels.Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway.A strong anti-inflammatory signature revealed by liver transcription profiling of Tmprss6-/- mice.Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice.Low intracellular iron increases the stability of matriptase-2.Hepcidin: A Critical Regulator of Iron Metabolism during HypoxiaIron-refractory iron deficiency anemia.Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia.Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage.A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis.Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice.Unraveling mechanisms regulating systemic iron homeostasis.An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia.Iron refractory iron deficiency anemiaIdentification and characterization of a novel murine allele of Tmprss6.Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver.Profile of Nancy C. AndrewsThe role of Matriptase-2 during the early postnatal development in humans.The liver: conductor of systemic iron balance.Iron metabolism: current facts and future directions.Iron homeostasis in the liver.Hypoxia-inducible factors link iron homeostasis and erythropoiesis.Molecular basis of iron-loading disorders.Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in β-thalassemia.Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice.Control of systemic iron homeostasis by the hemojuvelin-hepcidin axis.How I manage patients with atypical microcytic anaemia.Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling.
P2860
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P2860
Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Down-regulation of Bmp/Smad si ...... e of systemic iron homeostasis
@ast
Down-regulation of Bmp/Smad si ...... e of systemic iron homeostasis
@en
type
label
Down-regulation of Bmp/Smad si ...... e of systemic iron homeostasis
@ast
Down-regulation of Bmp/Smad si ...... e of systemic iron homeostasis
@en
prefLabel
Down-regulation of Bmp/Smad si ...... e of systemic iron homeostasis
@ast
Down-regulation of Bmp/Smad si ...... e of systemic iron homeostasis
@en
P2860
P1433
P1476
Down-regulation of Bmp/Smad si ...... e of systemic iron homeostasis
@en
P2093
Karin E Finberg
Rebecca L Whittlesey
P2860
P304
P356
10.1182/BLOOD-2009-05-224808
P407
P577
2010-03-03T00:00:00Z