Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. - Wikidata - wikimedia - TriplyDB

Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury.

Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury.

http://www.wikidata.org/entity/Q33838275

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Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation Bile acid signaling in metabolic disease and drug therapy Obstructive cholestasis induces TNF-alpha- and IL-1 -mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2 Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization.Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers.Intestinal detoxification limits the activation of hepatic pregnane X receptor by lithocholic acid.Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism.Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis.Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice.Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Population pharmacokinetic modeling of the association between 63396C->T pregnane X receptor polymorphism and unboosted atazanavir clearance.A functional cross-talk between liver X receptor-α and constitutive androstane receptor links lipogenesis and xenobiotic responses.Estrogen modulates transactivations of SXR-mediated liver X receptor response element and CAR-mediated phenobarbital response element in HepG2 cells Pregnane X receptor-mediated induction of Cyp3a by black cohosh.Impairment of bilirubin clearance and intestinal interleukin-6 expression in bile duct-ligated vitamin D receptor null mice Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation Benefit of farnesoid X receptor inhibition in obstructive cholestasis.Targeting the pregnane X receptor in liver injury.An updated review on drug-induced cholestasis: mechanisms and investigation of physicochemical properties and pharmacokinetic parameters.Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis.New perspectives for the treatment of cholestasis: lessons from basic science applied clinically.Small-molecule modulators of the constitutive androstane receptor.Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue.Nuclear receptors CAR and PXR in the regulation of hepatic metabolism.Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery.Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.Deciphering the roles of the constitutive androstane receptor in energy metabolism.Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-infected adults.Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy.Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.Transcriptional regulation of the human pregnane-X receptor.PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.

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P2860

Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury.

http://www.wikidata.org/entity/Q33838275

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2005 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2005年の論文

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Nuclear receptors constitutive ...... rate cholestatic liver injury.

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Nuclear receptors constitutive ...... rate cholestatic liver injury.

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Nuclear receptors constitutive ...... rate cholestatic liver injury.

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Nuclear receptors constitutive ...... rate cholestatic liver injury.

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Nuclear receptors constitutive ...... rate cholestatic liver injury.

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Nuclear receptors constitutive ...... rate cholestatic liver injury.

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Proceedings of the National Academy of Sciences of the United States of America

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Nuclear receptors constitutive ...... rate cholestatic liver injury.

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Catherine A M Stedman

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Christopher Liddle

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David D Moore

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Jacqueline G A Alvarez

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Junichiro Sonoda

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Michael Downes

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Sally A Coulter

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P2860

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

Induction of bilirubin clearance by the constitutive androstane receptor (CAR)

The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion

Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

Effects of long-term rifampicin administration in primary biliary cirrhosis

6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes.

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6

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102

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Ronald M. Evans

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8048431

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15684063

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548592

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