Thymidine kinase obliteration: creation of transgenic mice with controlled immune deficiency
about
Molecular neuroanatomy's "Three Gs": a primerAblation of a specific cell population by the replacement of a uniquely expressed gene with a toxin gene.Suppression of erythro-megakaryocytopoiesis and the induction of reversible thrombocytopenia in mice transgenic for the thymidine kinase gene targeted by the platelet glycoprotein alpha IIb promoter.The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrowTissue-specific expression of herpes simplex virus thymidine kinase gene delivered by adeno-associated virus inhibits the growth of human hepatocellular carcinoma in athymic mice.Suicide gene-mediated modulation of graft-versus-host disease.Combination gene delivery of the cell cycle inhibitor p27 with thymidine kinase enhances prodrug cytotoxicityTransgenic mice carrying the diphtheria toxin A chain gene under the control of the granzyme A promoter: expected depletion of cytotoxic cells and unexpected depletion of CD8 T cellsInducible and irreversible control of gene expression using a single transgene.Selective induction of toxicity to human cells expressing human immunodeficiency virus type 1 Tat by a conditionally cytotoxic adenovirus vector.Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor.Immunotoxin-mediated conditional disruption of specific neurons in transgenic mice.Specific ablation of human immunodeficiency virus Tat-expressing cells by conditionally toxic retrovirusesAn HSV-TK transgenic mouse model to evaluate elimination of fibroblasts for fibrosis therapy.Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation.Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor geneDevelopment of a cancer-marker activated enzymatic switch from the herpes simplex virus thymidine kinase.Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow.A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice.The herpes simplex virus type 1 thymidine kinase is expressed in the testes of transgenic mice under the control of a cryptic promoter.Targeted Type 2 Alveolar Cell Depletion. A Dynamic Functional Model for Lung Injury Repair.Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Müller Glia-Derived Progenitors During Zebrafish Retinal Regeneration.Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism.A Transgenic Rat for Specifically Inhibiting Adult Neurogenesis.Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS.Transgenic expression of PML/RARalpha impairs myelopoiesis.Chimeric antibody receptors (CARs): driving T-cell specificity to enhance anti-tumor immunityGenetic ablation of parietal cells in transgenic mice: a new model for analyzing cell lineage relationships in the gastric mucosaUltrasound-targeted HSVtk and Timp3 gene delivery for synergistically enhanced antitumor effects in hepatoma.Adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene inhibits vascular smooth muscle cell proliferation and neointima formation following balloon angioplasty of the rat carotid arteryReplication inhibition by nucleoside analogues of a recombinant Autographa californica multicapsid nuclear polyhedrosis virus harboring the herpes thymidine kinase gene driven by the IE-1(0) promoter: a new way to select recombinant baculovirusesThe reconstituted 'humanized liver' in TK-NOG mice is mature and functional.MIA (melanoma inhibitory activity) promoter mediated tissue-specific suicide gene therapy of malignant melanoma.Bone Marrow Stress Decreases Osteogenic Progenitors.Myf-5 and myoD genes are activated in distinct mesenchymal stem cells and determine different skeletal muscle cell lineages.Gene therapy for neurologic disease: benchtop discoveries to bedside applications. 1. The bench.B cell life span: a review.Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene.Conditional ablation and recovery of forebrain neurogenesis in the mouse.A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury.
P2860
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P2860
Thymidine kinase obliteration: creation of transgenic mice with controlled immune deficiency
description
1989 nî lūn-bûn
@nan
1989 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Thymidine kinase obliteration: ...... h controlled immune deficiency
@ast
Thymidine kinase obliteration: ...... h controlled immune deficiency
@en
type
label
Thymidine kinase obliteration: ...... h controlled immune deficiency
@ast
Thymidine kinase obliteration: ...... h controlled immune deficiency
@en
prefLabel
Thymidine kinase obliteration: ...... h controlled immune deficiency
@ast
Thymidine kinase obliteration: ...... h controlled immune deficiency
@en
P2093
P2860
P356
P1476
Thymidine kinase obliteration: ...... h controlled immune deficiency
@en
P2093
D Anderson
D D Richman
E Borrelli
R A Heyman
P2860
P304
P356
10.1073/PNAS.86.8.2698
P407
P577
1989-04-01T00:00:00Z