Repeat associated non-ATG translation initiation: one DNA, two transcripts, seven reading frames, potentially nine toxic entities! - Wikidata - wikimedia - TriplyDB

Repeat associated non-ATG translation initiation: one DNA, two transcripts, seven reading frames, potentially nine toxic entities!

Repeat associated non-ATG translation initiation: one DNA, two transcripts, seven reading frames, potentially nine toxic entities!

http://www.wikidata.org/entity/Q33851463

about

Toward precision medicine in amyotrophic lateral sclerosis A journey in bioinspired supramolecular chemistry: from molecular tweezers to small molecules that target myotonic dystrophy To Know How a Gene Works, We Need to Redefine It First but then, More Importantly, to Let the Cell Itself Decide How to Transcribe and Process Its RNAs Structural studies of CNG repeats Mechanisms of RNA-induced toxicity in CAG repeat disorders Modeling diseases of noncoding unstable repeat expansions using mutant pluripotent stem cells.Non-coding RNA in neural function, disease, and aging The intrinsic disorder alphabet. III. Dual personality of serine.Trinucleotide repeats: a structural perspective CGG allele size somatic mosaicism and methylation in FMR1 premutation alleles.Entrainment to periodic initiation and transition rates in a computational model for gene translation Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome Diced triplets expose neurons to RISC.MBNL proteins and their target RNAs, interaction and splicing regulation.The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.FRA2A is a CGG repeat expansion associated with silencing of AFF3 Repeat-associated non-AUG translation and its impact in neurodegenerative disease.Triplet repeat RNA structure and its role as pathogenic agent and therapeutic target Repeat Associated Non-AUG Translation (RAN Translation) Dependent on Sequence Downstream of the ATXN2 CAG Repeat RNA-binding protein misregulation in microsatellite expansion disorders RNA Structures as Mediators of Neurological Diseases and as Drug Targets.Variable Glutamine-Rich Repeats Modulate Transcription Factor Activity.Neurodegeneration the RNA way The disease-associated r(GGGGCC)n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structures Neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins.Bidirectional transcription of trinucleotide repeats: roles for excision repair.RNA-mediated toxicity in neurodegenerative disease Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration.Fragile X-associated tremor/ataxia syndrome (FXTAS): pathology and mechanisms.The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded C9ORF72 Inhibits the Proteasome Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.Expanded complexity of unstable repeat diseases.Ataxin-3 protein and RNA toxicity in spinocerebellar ataxia type 3: current insights and emerging therapeutic strategies.Small Molecule Recognition and Tools to Study Modulation of r(CGG)(exp) in Fragile X-Associated Tremor Ataxia Syndrome Advances in Sequencing Technologies for Understanding Hereditary Ataxias: A Review.Myotonic Dystrophy Type 2: An Update on Clinical Aspects, Genetic and Pathomolecular Mechanism.Myotonic dystrophy type 2 and modifier genes: an update on clinical and pathomolecular aspects.Nanoparticulate strategies for the treatment of polyglutamine diseases by halting the protein aggregation process.Biomarkers-A General Review.Drosophila Pur-α binds to trinucleotide-repeat containing cellular RNAs and translocates to the early oocyte.

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P2860

Repeat associated non-ATG translation initiation: one DNA, two transcripts, seven reading frames, potentially nine toxic entities!

http://www.wikidata.org/entity/Q33851463

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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Repeat associated non-ATG tran ...... tentially nine toxic entities!

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Repeat associated non-ATG tran ...... tentially nine toxic entities!

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Repeat associated non-ATG tran ...... tentially nine toxic entities!

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Repeat associated non-ATG tran ...... tentially nine toxic entities!

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Repeat associated non-ATG tran ...... tentially nine toxic entities!

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Repeat associated non-ATG tran ...... tentially nine toxic entities!

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Repeat associated non-ATG tran ...... tentially nine toxic entities!

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P2093

Christopher E Pearson

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P2860

Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene

Polyalanine and polyserine frameshift products in Huntington's disease

Regulation of translation initiation in eukaryotes: mechanisms and biological targets

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

A unifying genetic model for facioscapulohumeral muscular dystrophy

Early onset prion disease from octarepeat expansion correlates with copper binding properties

RNA gain-of-function in spinocerebellar ataxia type 8.

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin.

Functional insights from the distribution and role of homopeptide repeat-containing proteins

FSHD: a repeat contraction disease finally ready to expand (our understanding of its pathogenesis)

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e1002018

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scholarly article

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10.1371/JOURNAL.PGEN.1002018

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21423665

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mutant proteins

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3053344

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