The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. - Wikidata - wikimedia - TriplyDB

The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

http://www.wikidata.org/entity/Q33852211

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Telomerase modulates Wnt signalling by association with target gene chromatin Telomerase reverse transcriptase regulates microRNAs An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA Involvement of telomerase reverse transcriptase in heterochromatin maintenance Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria High incidence of rapid telomere loss in telomerase-deficient Caenorhabditis elegans Telomeres, NAFLD and Chronic Liver Disease Therapeutic targeting of replicative immortality Differential Protein Distribution between the Nucleus and Mitochondria: Implications in Aging The MAPK pathway signals telomerase modulation in response to isothiocyanate-induced DNA damage of human liver cancer cells HPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytes TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program Telomerase deficiency affects the formation of chromosomal translocations by homologous recombination in Saccharomyces cerevisiae.A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis.Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita Comparative proteomics analysis of cardiac muscle samples from pufferfish Takifugu rubripes exposed to excessive fluoride: initial molecular response to fluorosis.Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase Telomeres: protecting chromosomes against genome instability The cancer theory of pulmonary arterial hypertension.Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice Telomerase reverse transcriptase in the regulation of gene expression.Bypass of senescence, immortalization, and transformation of human hematopoietic progenitor cells.Healthy aging and disease: role for telomere biology?Effects of mitochondrial translocation of telomerase on drug resistance in hepatocellular carcinoma cells.Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas.Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase Impact of mitochondrial telomerase over-expression on drug resistance of hepatocellular carcinoma.Prolonged self-renewal activity unmasks telomerase control of telomere homeostasis and function of mouse hematopoietic stem cells Telomerase expression and telomere length in breast cancer and their associations with adjuvant treatment and disease outcome.Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells.Improving cell therapy--experiments using transplanted telomerase-immortalized cells in immunodeficient mice PinX1: a sought-after major tumor suppressor at human chromosome 8p23 Separation of telomerase functions by reverse genetics Characterization and fate of telomerase-expressing epithelia during kidney repair Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity.The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression.Intratumoral diversity of telomere length in individual neuroblastoma tumors.Saccharomyces cerevisiae as a model for the study of extranuclear functions of mammalian telomerase Telomerase core components protect Candida telomeres from aberrant overhang accumulation.

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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

http://www.wikidata.org/entity/Q33852211

description

2005 nî lūn-bûn

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

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Proceedings of the National Academy of Sciences of the United States of America

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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses

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Jennifer L Currier

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Judith B Manola

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Kathleen Collins

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Kenkichi Masutomi

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Peter M Lansdorp

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Shridar Ganesan

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William C Hahn

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Zuzana Tothova

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P2860

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Extension of life-span by introduction of telomerase into normal human cells

Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends.

Homologous recombination generates T-loop-sized deletions at human telomeres

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Regulation of heterochromatin by histone methylation and small RNAs

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

A DNA damage checkpoint response in telomere-initiated senescence

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

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102

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Richard Possemato

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