SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.
about
Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cellsIdentification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFATPRAM-1 is required for optimal integrin-dependent neutrophil functionAn essential role for RasGRP1 in mast cell function and IgE-mediated allergic responseClnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cellsPhosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cellsPhospholipase D2 acts as an essential adaptor protein in the activation of Syk in antigen-stimulated mast cellsFer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cellsAdaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: differential involvement of the FYB SH3 domainDisruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells.Transcriptome analysis reveals potential mechanisms underlying differential heart development in fast- and slow-growing broilers under heat stress.Small interfering RNA screen for phosphatases involved in IgE-mediated mast cell degranulation.Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.Tyrosines in the carboxyl terminus regulate Syk kinase activity and functionIndependent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activationModulation of T-cell receptor signal transduction by herpesvirus signaling adaptor protein.Adapters in the organization of mast cell signaling.Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cellsEvidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and SykHerpesvirus saimiri STP-A oncoprotein utilizes Src family protein tyrosine kinase and tumor necrosis factor receptor-associated factors to elicit cellular signal transductionOnce phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulationRegulation of mast cell survival and function by tuberous sclerosis complex 1.Regulation of mast cell responses in health and disease.Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells.Signal transduction and chemotaxis in mast cellsFc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane.Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling.The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation.Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells.IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice.Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Fcgamma receptors I and II/IIINew insights on mast cell activation via the high affinity receptor for IgEMutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis.Mechanisms of mast cell signaling in anaphylaxis.The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and FunctionCoordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76Understanding signal integration through targeted mutations of an adapter protein.Immunodeficiency due to defects in store-operated calcium entry.
P2860
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P2860
SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.
@ast
SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.
@en
type
label
SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.
@ast
SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.
@en
prefLabel
SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.
@ast
SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.
@en
P2093
P2860
P1476
SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.
@en
P2093
H C Oettgen
J M Lu-Kuo
T R Martin
V I Pivniouk
P2860
P304
P407
P577
1999-06-01T00:00:00Z