Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IkappaB(alpha) degradation - Wikidata - wikimedia - TriplyDB

Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IkappaB(alpha) degradation

Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IkappaB(alpha) degradation

http://www.wikidata.org/entity/Q33855223

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Alterations of the intracellular peptidome in response to the proteasome inhibitor bortezomib Dual inhibition of canonical and noncanonical NF-κB pathways demonstrates significant antitumor activities in multiple myeloma Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC)Blocking autophagy prevents bortezomib-induced NF-κB activation by reducing I-κBα degradation in lymphoma cells Calmodulin protects androgen receptor from calpain-mediated breakdown in prostate cancer cells Regulatory role of proteasome in determination of platelet life span A phase I trial of bortezomib in combination with epirubicin, carboplatin and capecitabine (ECarboX) in advanced oesophagogastric adenocarcinoma.Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia MCPIP1 contributes to the toxicity of proteasome inhibitor MG-132 in HeLa cells by the inhibition of NF-κB The docking protein p130Cas regulates cell sensitivity to proteasome inhibition.Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals Monoubiquitination of nuclear RelA negatively regulates NF-κB activity independent of proteasomal degradation Astragalus saponins modulates colon cancer development by regulating calpain-mediated glucose-regulated protein expression.Drugs acting on homeostasis: challenging cancer cell adaptation.Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-{kappa}B signaling pathway.Calpains as potential anti-cancer targets NF-κB addiction and its role in cancer: 'one size does not fit all'.Apoptotic role of IKK in T-ALL therapeutic response.Calpain inhibition attenuates apoptosis of retinal ganglion cells in acute optic neuritis.NF-κB signaling mediates acquired resistance after PARP inhibition.Oncogenic role of EAPII in lung cancer development and its activation of the MAPK-ERK pathway.Autophagy promotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-β1.Regulation of dimethyl-fumarate toxicity by proteasome inhibitors Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling.Combination chemotherapy increases cytotoxicity of multiple myeloma cells by modification of nuclear factor (NF)-κB activity.Obatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC- and ABC-DLBCL cells in vitro and in vivo Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB.MTDH is an oncogene in multiple myeloma, which is suppressed by Bortezomib treatment.Calpain A modulates Toll responses by limited Cactus/IκB proteolysis.Proteasome inhibitor MG-132 induces MCPIP1 expression Epigenetic roles of MLL oncoproteins are dependent on NF-κB Long-term incubation with proteasome inhibitors (PIs) induces IκBα degradation via the lysosomal pathway in an IκB kinase (IKK)-dependent and IKK-independent manner Phase I trial of bortezomib and dacarbazine in melanoma and soft tissue sarcoma.Proteasome inhibition increases recruitment of IκB kinase β (IKKβ), S536P-p65, and transcription factor EGR1 to interleukin-8 (IL-8) promoter, resulting in increased IL-8 production in ovarian cancer cells.Reverse the Resistance to PARP Inhibitors.Histone deacetylase inhibitors: potential targets responsible for their anti-cancer effect.The calpain system and cancer.Proteasome inhibitors - molecular basis and current perspectives in multiple myeloma.Bortezomib and fenretinide induce synergistic cytotoxicity in mantle cell lymphoma through apoptosis, cell-cycle dysregulation, and IκBα kinase downregulation.AMPKα2 reduces renal epithelial transdifferentiation and inflammation after injury through interaction with CK2β.

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Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IkappaB(alpha) degradation

http://www.wikidata.org/entity/Q33855223

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Proteasome inhibitor PS-341 (b ...... ent IkappaB(alpha) degradation

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Proteasome inhibitor PS-341 (b ...... ent IkappaB(alpha) degradation

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type

label

Proteasome inhibitor PS-341 (b ...... ent IkappaB(alpha) degradation

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Proteasome inhibitor PS-341 (b ...... ent IkappaB(alpha) degradation

@en

prefLabel

Proteasome inhibitor PS-341 (b ...... ent IkappaB(alpha) degradation

@ast

Proteasome inhibitor PS-341 (b ...... ent IkappaB(alpha) degradation

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JBC.M109.072694

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Journal of Biological Chemistry

P1476

Proteasome inhibitor PS-341 (b ...... ent IkappaB(alpha) degradation

@en

P2093

Chunyang Li

http://www.w3.org/2001/XMLSchema#string

Fadlo R Khuri

http://www.w3.org/2001/XMLSchema#string

Ping Yue

http://www.w3.org/2001/XMLSchema#string

Shi-Yong Sun

http://www.w3.org/2001/XMLSchema#string

Shuzhen Chen

http://www.w3.org/2001/XMLSchema#string

Xingming Deng

http://www.w3.org/2001/XMLSchema#string

P2860

To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis

Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis

Good cop, bad cop: the different faces of NF-kappaB

Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation

Nuclear factor-kappaB in cancer development and progression

Preclinical data with bortezomib in lung cancer.

Proteasome inhibitors in lung cancer.

Development of the proteasome inhibitor Velcade (Bortezomib).

Proteolytic signaling by TNFalpha: caspase activation and IkappaB degradation.

The proteasome: a suitable antineoplastic target.

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20335171

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2871478

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