Deletion of Ile1 changes the mechanism of streptokinase: evidence for the molecular sexuality hypothesis.
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Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activationPEGylation of Truncated Streptokinase Leads to Formulation of a Useful Drug with Ameliorated AttributesStructure-function analysis of the streptokinase amino terminus (residues 1-59).Skizzle is a novel plasminogen- and plasmin-binding protein from Streptococcus agalactiae that targets proteins of human fibrinolysis to promote plasmin generationRapid binding of plasminogen to streptokinase in a catalytic complex reveals a three-step mechanism.Characterization of PauB, a novel broad-spectrum plasminogen activator from Streptococcus uberisEngineering streptokinase for generation of active site-labeled plasminogen analogs.Pathogen activators of plasminogenAmino-Terminal Fusion of Epidermal Growth Factor 4,5,6 Domains of Human Thrombomodulin on Streptokinase Confers Anti-Reocclusion Characteristics along with Plasmin-Mediated Clot Specificity.Streptococcus uberis plasminogen activator (SUPA) activates human plasminogen through novel species-specific and fibrin-targeted mechanisms.Activity Regulation by Fibrinogen and Fibrin of Streptokinase from Streptococcus Pyogenes.Role of the streptokinase alpha-domain in the interactions of streptokinase with plasminogen and plasminStructural basis for reduced staphylocoagulase-mediated bovine prothrombin activationVon Willebrand factor-binding protein is a hysteretic conformational activator of prothrombinFull time course kinetics of the streptokinase-plasminogen activation pathway.Plasminogen substrate recognition by the streptokinase-plasminogen catalytic complex is facilitated by Arg253, Lys256, and Lys257 in the streptokinase beta-domain and kringle 5 of the substrate.Involvement of a nine-residue loop of streptokinase in the generation of macromolecular substrate specificity by the activator complex through interaction with substrate kringle domains.Leucine 42 in the fibronectin motif of streptokinase plays a critical role in fibrin-independent plasminogen activation.Allosteric peptide activators of pro-hepatocyte growth factor stimulate Met signaling.Reprogrammed streptokinases develop fibrin-targeting and dissolve blood clots with more potency than tissue plasminogen activator.Identification of a new exosite involved in catalytic turnover by the streptokinase-plasmin activator complex during human plasminogen activation.Site-restricted plasminogen activation mediated by group A streptococcal streptokinase variants.Rapid-reaction kinetic characterization of the pathway of streptokinase-plasmin catalytic complex formation.Identification through combinatorial random and rational mutagenesis of a substrate-interacting exosite in the gamma domain of streptokinase.Resolution of conformational activation in the kinetic mechanism of plasminogen activation by streptokinase.Chimerism reveals a role for the streptokinase Beta -domain in nonproteolytic active site formation, substrate, and inhibitor interactions.alpha Domain deletion converts streptokinase into a fibrin-dependent plasminogen activator through mechanisms akin to staphylokinase and tissue plasminogen activator.The mechanism of a bacterial plasminogen activator intermediate between streptokinase and staphylokinase.Dual functionality of β-tryptase protomers as both proteases and cofactors in the active tetramer.Domain truncation studies reveal that the streptokinase-plasmin activator complex utilizes long range protein-protein interactions with macromolecular substrate to maximize catalytic turnover.
P2860
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P2860
Deletion of Ile1 changes the mechanism of streptokinase: evidence for the molecular sexuality hypothesis.
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Deletion of Ile1 changes the m ...... olecular sexuality hypothesis.
@ast
Deletion of Ile1 changes the m ...... olecular sexuality hypothesis.
@en
type
label
Deletion of Ile1 changes the m ...... olecular sexuality hypothesis.
@ast
Deletion of Ile1 changes the m ...... olecular sexuality hypothesis.
@en
prefLabel
Deletion of Ile1 changes the m ...... olecular sexuality hypothesis.
@ast
Deletion of Ile1 changes the m ...... olecular sexuality hypothesis.
@en
P2093
P356
P1433
P1476
Deletion of Ile1 changes the m ...... olecular sexuality hypothesis.
@en
P2093
P304
P356
10.1021/BI981915H
P407
P577
1999-04-01T00:00:00Z