Structure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction.
about
Butyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behaviorModeling of pharmacokinetics of cocaine in human reveals the feasibility for development of enzyme therapies for drugs of abusePreparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine.Enzyme-therapy approaches for the treatment of drug overdose and addiction.Development of organophosphate hydrolase activity in a bacterial homolog of human cholinesterasePharmacokinetic strategies for treatment of drug overdose and addiction.Catalytic bioscavengers against toxic esters, an alternative approach for prophylaxis and treatments of poisonings.Reaction Pathway and Free Energy Profile for Cocaine Hydrolase-Catalyzed Hydrolysis of (-)-CocaineFundamental reaction mechanism and free energy profile for (-)-cocaine hydrolysis catalyzed by cocaine esteraseRecent progress in protein drug design and discovery with a focus on novel approaches to the development of anti-cocaine medications.Modeling in vitro inhibition of butyrylcholinesterase using molecular docking, multi-linear regression and artificial neural network approachesReaction Pathway for Cocaine Hydrolase-Catalyzed Hydrolysis of (+)-Cocaine.Biologics to treat substance use disorders: Current status and new directionsReaction pathway and free energy profiles for butyrylcholinesterase-catalyzed hydrolysis of acetylthiocholine.Reaction pathway and free-energy barrier for reactivation of dimethylphosphoryl-inhibited human acetylcholinesteraseCatalytic activities of a cocaine hydrolase engineered from human butyrylcholinesterase against (+)- and (-)-cocaine.Reaction mechanism for cocaine esterase-catalyzed hydrolyses of (+)- and (-)-cocaine: unexpected common rate-determining step.Reaction pathway and free energy profile for butyrylcholinesterase-catalyzed hydrolysis of acetylcholine.Density functional theory investigation of cocaine water complexes.Discovery of a butyrylcholinesterase-specific probe via a structure-based design strategy.Synthetic, Switchable Enzymes.
P2860
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P2860
Structure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction.
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structure-and-mechanism-based ...... ocaine overdose and addiction.
@ast
Structure-and-mechanism-based ...... ocaine overdose and addiction.
@en
type
label
Structure-and-mechanism-based ...... ocaine overdose and addiction.
@ast
Structure-and-mechanism-based ...... ocaine overdose and addiction.
@en
prefLabel
Structure-and-mechanism-based ...... ocaine overdose and addiction.
@ast
Structure-and-mechanism-based ...... ocaine overdose and addiction.
@en
P2860
P356
P1476
Structure-and-mechanism-based ...... ocaine overdose and addiction.
@en
P2093
Chang-Guo Zhan
Fang Zheng
P2860
P304
P356
10.1039/B716268E
P577
2007-12-05T00:00:00Z