LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures. - Wikidata - wikimedia - TriplyDB

LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures.

LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures.

http://www.wikidata.org/entity/Q33860855

about

Systems Biology-Based Investigation of Cellular Antiviral Drug Targets Identified by Gene-Trap Insertional Mutagenesis Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression Public data and open source tools for multi-assay genomic investigation of disease Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease Cheminformatics Research at the Unilever Centre for Molecular Science Informatics Cambridge Elucidating the modes of action for bioactive compounds in a cell-specific manner by large-scale chemically-induced transcriptomics Systematic Quality Control Analysis of LINCS Data Systematic discovery of drug action mechanisms by an integrated chemical genomics approach: identification of functional disparities between azacytidine and decitabine Explore Small Molecule-induced Genome-wide Transcriptional Profiles for Novel Inflammatory Bowel Disease Drug High throughput toxicity screening and intracellular detection of nanomaterials Representing high throughput expression profiles via perturbation barcodes reveals compound targets Lean Big Data integration in systems biology and systems pharmacology.Compound signature detection on LINCS L1000 big data.Publisher’s Note:Abstraction for data integration:Fusing mammalian molecular, cellular and phenotype big datasets for better knowledge extraction.The amniotic fluid transcriptome as a guide to understanding fetal disease.Big-data-based edge biomarkers: study on dynamical drug sensitivity and resistance in individuals.Role of innate immunity-triggered pathways in the pathogenesis of Sickle Cell Disease: a meta-analysis of gene expression studies An in vivo molecular response analysis of colorectal cancer treated with Astragalus membranaceus extract PhenoMeter: A Metabolome Database Search Tool Using Statistical Similarity Matching of Metabolic Phenotypes for High-Confidence Detection of Functional Links Reduced-representation Phosphosignatures Measured by Quantitative Targeted MS Capture Cellular States and Enable Large-scale Comparison of Drug-induced Phenotypes Detection and removal of spatial bias in multiwell assays.Proteogenomics connects somatic mutations to signalling in breast cancer.Real-Time Biological Annotation of Synthetic Compounds.A review of connectivity map and computational approaches in pharmacogenomics.Fine-tuning of macrophage activation using synthetic rocaglate derivatives.In silico methods for drug repurposing and pharmacology A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine.Concerted changes in transcriptional regulation of genes involved in DNA methylation, demethylation, and folate-mediated one-carbon metabolism pathways in the NCI-60 cancer cell line panel in response to cancer drug treatment The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins.Virtual screening-driven repositioning of etoposide as CD44 antagonist in breast cancer cells Importance of rare gene copy number alterations for personalized tumor characterization and survival analysis.A cloud-based workflow to quantify transcript-expression levels in public cancer compendia.Individualized network-based drug repositioning infrastructure for precision oncology in the panomics era.Effects of mannose-binding lectin on pulmonary gene expression and innate immune inflammatory response to ozone.l1kdeconv: an R package for peak calling analysis with LINCS L1000 data.Detecting and removing multiplicative spatial bias in high-throughput screening technologies.In silico polypharmacology of natural products.Identification of novel chemotherapeutic strategies for metastatic uveal melanoma.Identification of clinically predictive metagenes that encode components of a network coupling cell shape to transcription by image-omics.Functional variomics and network perturbation: connecting genotype to phenotype in cancer.

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P2860

LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures.

http://www.wikidata.org/entity/Q33860855

description

2014 nî lūn-bûn

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2014 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հունիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

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Nucleic Acids Research

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Aravind Subramanian

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Christopher M Tan

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Corey Flynn

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Edward Y Chen

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Jeremy L Muhlich

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Nicolas F Fernandez

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Qiaonan Duan

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Todd R Golub

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P2860

WikiPathways: pathway editing for the people

Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease

PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro

KEGG: kyoto encyclopedia of genes and genomes

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Cluster analysis and display of genome-wide expression patterns

NCBI GEO: mining tens of millions of expression profiles--database and tools update

Reactome: a knowledgebase of biological pathways

WebGestalt: an integrated system for exploring gene sets in various biological contexts.

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

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W449-60

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scholarly article

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10.1093/NAR/GKU476

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Web Server issue

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42

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Peter K. Sorger

Andrew D Rouillard

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2014-06-06T00:00:00Z

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262929334

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24906883

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