The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice. - Wikidata - wikimedia - TriplyDB

The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice.

The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice.

http://www.wikidata.org/entity/Q33861156

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DNA vaccination with a gene encoding Toxoplasma gondii Rhoptry Protein 17 induces partial protective immunity against lethal challenge in mice Recent advances in understanding apicomplexan parasites Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface Secreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis?Wine glasses and hourglasses: Non-adaptive complexity of vesicle traffic in microbial eukaryotes Serum Albumin Stimulates Protein Kinase G-dependent Microneme Secretion in Toxoplasma gondii Genome-wide analysis of gene expression and protein secretion of Babesia canis during virulent infection identifies potential pathogenicity factors.Toxoplasma's arms race with the host interferon response: a ménage à trois of ROPs.The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes.Toxoplasma gondii development of its replicative niche: in its host cell and beyond.The Toxoplasma pseudokinase ROP5 is an allosteric inhibitor of the immunity-related GTPases.Functional analysis of rhomboid proteases during Toxoplasma invasion.Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination.Forward genetics screens using macrophages to identify Toxoplasma gondii genes important for resistance to IFN-γ-dependent cell autonomous immunity AMA1-deficient Toxoplasma gondii parasites transiently colonize mice and trigger an innate immune response that leads to long-lasting protective immunity.MSCA: a spectral comparison algorithm between time series to identify protein-protein interactions.Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii.K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells.An in vitro model of intestinal infection reveals a developmentally regulated transcriptome of Toxoplasma sporozoites and a NF-κB-like signature in infected host cells.Toxoplasma gondii GRA7-Induced TRAF6 Activation Contributes to Host Protective Immunity Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes.Identification of new palmitoylated proteins in Toxoplasma gondii.Analysis of Noncanonical Calcium-Dependent Protein Kinases in Toxoplasma gondii by Targeted Gene Deletion Using CRISPR/Cas9.Functional Analysis of the Role of Toxoplasma gondii Nucleoside Triphosphate Hydrolases I and II in Acute Mouse Virulence and Immune Suppression.Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity.The Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection.Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ-mediated host defenses.The Toxoplasma gondii rhoptry protein ROP18 is an Irga6-specific kinase and regulated by the dense granule protein GRA7.Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity.Functional Characterization of Rhoptry Kinome in the Virulent Toxoplasma gondii RH Strain.Rhoptry protein 5 (ROP5) Is a Key Virulence Factor in Neospora caninum.Identification of small molecule inhibitors that block the Toxoplasma gondii rhoptry kinase ROP18.Toxoplasma Effectors Targeting Host Signaling and Transcription.The serine/threonine phosphatases of apicomplexan parasites.Characterization of the Neospora caninum NcROP40 and NcROP2Fam-1 rhoptry proteins during the tachyzoite lytic cycle.Enhancement of the protective efficacy of a ROP18 vaccine against chronic toxoplasmosis by nasal route.Towards vaccine against toxoplasmosis: evaluation of the immunogenic and protective activity of recombinant ROP5 and ROP18 Toxoplasma gondii proteins.The Rhoptry Pseudokinase ROP54 Modulates Toxoplasma gondii Virulence and Host GBP2 Loading.Host-Toxoplasma gondii Coadaptation Leads to Fine Tuning of the Immune Response.Functional Analysis of the Rhoptry Kinome during Chronic Toxoplasma gondii Infection.

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The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice.

http://www.wikidata.org/entity/Q33861156

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2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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The Toxoplasma pseudokinase RO ...... ntrol acute virulence in mice.

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The Toxoplasma pseudokinase RO ...... ntrol acute virulence in mice.

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The Toxoplasma pseudokinase RO ...... ntrol acute virulence in mice.

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The Toxoplasma pseudokinase RO ...... ntrol acute virulence in mice.

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The Toxoplasma pseudokinase RO ...... ntrol acute virulence in mice.

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J.CHOM.2014.04.002

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Cell Host & Microbe

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The Toxoplasma pseudokinase RO ...... ntrol acute virulence in mice.

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Aditi Alaganan

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Benjamin E Turk

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Hua Jane Lou

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Keliang Tang

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Ronald D Etheridge

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P2860

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole

Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence

Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP

Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondii.

The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18

A Conserved Non-canonical Motif in the Pseudoactive Site of the ROP5 Pseudokinase Domain Mediates Its Effect on Toxoplasma Virulence

Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

The tandem affinity purification (TAP) method: a general procedure of protein complex purification

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification

Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii

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24832449

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