A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation - Wikidata - wikimedia - TriplyDB

A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation

A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation

http://www.wikidata.org/entity/Q33861874

about

Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 mice.Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models.Targeting the pregnane X receptor in liver injury.Expression of Human DNAJ (Heat Shock Protein-40) B3 in Humanized UDP-glucuronosyltransferase 1 Mice Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11).Utilization of glutathione S-transferase Mu 1- and Theta 1-null mice as animal models for absorption, distribution, metabolism, excretion and toxicity studies.Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications.Transcriptional regulation of human UDP-glucuronosyltransferase genes.Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells.Current challenges and controversies in drug-induced liver injury.Cadmium and arsenic override NF-κB developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia.Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity.Glucuronidation of drugs in humanized UDP-glucuronosyltransferase 1 mice: Similarity with glucuronidation in human liver microsomes.Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα.Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans.Altered gene expression profiles in the lungs of benzo[a]pyrene-exposed mice in the presence of lipopolysaccharide-induced pulmonary inflammation.Discovery pharmacokinetic studies in mice using serial microsampling, dried blood spots and microbore LC-MS/MS.

P2860

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P2860

A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation

http://www.wikidata.org/entity/Q33861874

description

2010 nî lūn-bûn

@nan

2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

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2010年論文

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2010年论文

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name

A humanized UGT1 mouse model e ...... T1A1-dependent glucuronidation

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A humanized UGT1 mouse model e ...... T1A1-dependent glucuronidation

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type

label

A humanized UGT1 mouse model e ...... T1A1-dependent glucuronidation

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A humanized UGT1 mouse model e ...... T1A1-dependent glucuronidation

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A humanized UGT1 mouse model e ...... T1A1-dependent glucuronidation

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A humanized UGT1 mouse model e ...... T1A1-dependent glucuronidation

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Drug Metabolism and Disposition

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A humanized UGT1 mouse model e ...... T1A1-dependent glucuronidation

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P2093

Deirdre Beaton La Placa

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Hongliang Cai

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Jeffrey C Stevens

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Kathy Hotz

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Nghia Nguyen

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Robert H Tukey

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Shujuan Chen

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Vincent Peterkin

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Young-Sun Yang

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P2860

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine

Human UDP-glucuronosyltransferases: metabolism, expression, and disease

Inherited disorders of bilirubin metabolism

Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity

Uridine diphosphate glucuronosyltransferase (UGT) 1A1 and irinotecan: practical pharmacogenomics arrives in cancer therapy

Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex

Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1/2 be predicted from in-vivo rat data?

Use of cloned and expressed human UDP-glucuronosyltransferases for the assessment of human drug conjugation and identification of potential drug interactions.

Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes.

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879-886

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10.1124/DMD.109.030130

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5

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38

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41399489

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20124398

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2872941

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