Characterization and functional ordering of Slu7p and Prp17p during the second step of pre-mRNA splicing in yeast.
about
Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicingSplicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleusHuman homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicingThe HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicasesPrp8 protein: at the heart of the spliceosomePRP16, a DEAH-box RNA helicase, is recruited to the spliceosome primarily via its nonconserved N-terminal domainIdentification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle controlGenetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiaeCrystal structure of the functional domain of the splicing factor Prp18The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability.Extensive genetic interactions between PRP8 and PRP17/CDC40, two yeast genes involved in pre-mRNA splicing and cell cycle progression.Evidence for a role of Sky1p-mediated phosphorylation in 3' splice site recognition involving both Prp8 and Prp17/Slu4.How Slu7 and Prp18 cooperate in the second step of yeast pre-mRNA splicing.Spliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicingMutational analysis identifies two separable roles of the Saccharomyces cerevisiae splicing factor Prp18.The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.A novel splicing factor, Yju2, is associated with NTC and acts after Prp2 in promoting the first catalytic reaction of pre-mRNA splicing.Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing.Prp22, a DExH-box RNA helicase, plays two distinct roles in yeast pre-mRNA splicingFunctional analyses of interacting factors involved in both pre-mRNA splicing and cell cycle progression in Saccharomyces cerevisiae.The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function.Snt309p, a component of the Prp19p-associated complex that interacts with Prp19p and associates with the spliceosome simultaneously with or immediately after dissociation of U4 in the same manner as Prp19p.Central region of the human splicing factor Hprp3p interacts with Hprp4pGenetic and functional interaction of evolutionarily conserved regions of the Prp18 protein and the U5 snRNA.Interaction of the yeast DExH-box RNA helicase prp22p with the 3' splice site during the second step of nuclear pre-mRNA splicingMolecular genetic analysis of U2AF59 in Schizosaccharomyces pombe: differential sensitivity of introns to mutational inactivation.Identification of a U2/U6 helix la mutant that influences 3' splice site selection during nuclear pre-mRNA splicing.DEAH-box ATPase Prp16 has dual roles in remodeling of the spliceosome in catalytic steps.Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p.Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling.U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicingThe Prp18 protein stabilizes the interaction of both exons with the U5 snRNA during the second step of pre-mRNA splicingFunctional roles of protein splicing factors.Link of NTR-mediated spliceosome disassembly with DEAH-box ATPases Prp2, Prp16, and Prp22.Cwc25 is a novel splicing factor required after Prp2 and Yju2 to facilitate the first catalytic reactionNonsense-mediated mRNA decay mutes the splicing defects of spliceosome component mutations.The mechanism of the second step of pre-mRNA splicing.Genome-wide analysis of pre-mRNA splicing: intron features govern the requirement for the second-step factor, Prp17 in Saccharomyces cerevisiae and Schizosaccharomyces pombe.Reversible inhibition of the second step of splicing suggests a possible role of zinc in the second step of splicing.Functional and physical interaction between the yeast splicing factors Slu7 and Prp18.
P2860
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P2860
Characterization and functional ordering of Slu7p and Prp17p during the second step of pre-mRNA splicing in yeast.
description
1995 nî lūn-bûn
@nan
1995 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Characterization and functiona ...... of pre-mRNA splicing in yeast.
@ast
Characterization and functiona ...... of pre-mRNA splicing in yeast.
@en
type
label
Characterization and functiona ...... of pre-mRNA splicing in yeast.
@ast
Characterization and functiona ...... of pre-mRNA splicing in yeast.
@en
prefLabel
Characterization and functiona ...... of pre-mRNA splicing in yeast.
@ast
Characterization and functiona ...... of pre-mRNA splicing in yeast.
@en
P2093
P2860
P356
P1476
Characterization and functiona ...... of pre-mRNA splicing in yeast.
@en
P2093
P2860
P304
P356
10.1073/PNAS.92.21.9687
P407
P577
1995-10-01T00:00:00Z