Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation. - Wikidata - wikimedia - TriplyDB

Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation.

Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation.

http://www.wikidata.org/entity/Q33868529

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Role of Nrf2 in oxidative stress and toxicity Flesh quality loss in response to dietary isoleucine deficiency and excess in fish: a link to impaired Nrf2-dependent antioxidant defense in muscle Nrf2 plays a pivotal role in protection against burn trauma-induced intestinal injury and death Nrf2 regulates chronic lung inflammation and B-cell responses to nontypeable Haemophilus influenzae Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease Nrf2 is required for normal postnatal bone acquisition in mice RNAi Screen for NRF2 Inducers Identifies Targets That Rescue Primary Lung Epithelial Cells from Cigarette Smoke Induced Radical Stress Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer.An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1: a longitudinal retrospective cohort study.Inflammatory transcriptome profiling of human monocytes exposed acutely to cigarette smoke.Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers.Beneficial role of Nrf2 in regulating NADPH generation and consumption.Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts.Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol.Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function Experimental therapeutics of Nrf2 as a target for prevention of bacterial exacerbations in COPD Major differences among chemopreventive organoselenocompounds in the sustained elevation of cytoprotective genes.Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease.Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS T Lymphocyte-Specific Activation of Nrf2 Protects from AKI.Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model Kidney epithelium specific deletion of kelch-like ECH-associated protein 1 (Keap1) causes hydronephrosis in mice.Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines.NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation.Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle.Nrf2 deficiency in dendritic cells enhances the adjuvant effect of ambient ultrafine particles on allergic sensitization.Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus.Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease.Role of transcription factors in the pathogenesis of asthma and COPD.Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression.Progression inference for somatic mutations in cancer.Sulforaphane inhibits de novo synthesis of IL-8 and MCP-1 in human epithelial cells generated by cigarette smoke extract.Resveratrol protects against cigarette smoke-induced oxidative damage and pulmonary inflammation.Berberine attenuates cigarette smoke-induced acute lung inflammation.Age-related cataracts: Role of unfolded protein response, Ca2+ mobilization, epigenetic DNA modifications, and loss of Nrf2/Keap1 dependent cytoprotection.Cell-specific Activation of the Nrf2 Antioxidant Pathway Increases Mucosal Inflammation in Acute but Not in Chronic Colitis.Soyabean glycinin depresses intestinal growth and function in juvenile Jian carp (Cyprinus carpio var Jian): protective effects of glutamine.

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P2860

Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation.

http://www.wikidata.org/entity/Q33868529

description

2009 nî lūn-bûn

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2009 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2009 թվականի հունիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Deletion of Keap1 in the lung ...... ative stress and inflammation.

@ast

Deletion of Keap1 in the lung ...... ative stress and inflammation.

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type

label

Deletion of Keap1 in the lung ...... ative stress and inflammation.

@ast

Deletion of Keap1 in the lung ...... ative stress and inflammation.

@en

prefLabel

Deletion of Keap1 in the lung ...... ative stress and inflammation.

@ast

Deletion of Keap1 in the lung ...... ative stress and inflammation.

@en

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RCMB.2009-0054OC

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American Journal of Respiratory Cell and Molecular Biology

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Deletion of Keap1 in the lung ...... ative stress and inflammation.

@en

P2093

Anju Singh

http://www.w3.org/2001/XMLSchema#string

David J Blake

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Deepti Malhotra

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Edward Gabrielson

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Ponvijay Kombairaju

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Rubin M Tuder

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Shyam Biswal

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Thomas J Mariani

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P2860

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

Nrf2-Keap1 defines a physiologically important stress response mechanism

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

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524-536

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10.1165/RCMB.2009-0054OC

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5

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42

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19520915

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2874439

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