Route to three-dimensional fragments using diversity-oriented synthesis. - Wikidata - wikimedia - TriplyDB

Route to three-dimensional fragments using diversity-oriented synthesis.

Route to three-dimensional fragments using diversity-oriented synthesis.

http://www.wikidata.org/entity/Q33868796

about

Diversity-oriented synthetic strategies applied to cancer chemical biology and drug discovery Assembly of a π–π stack of ligands in the binding site of an acetylcholine-binding protein Natural-product-derived fragments for fragment-based ligand discovery Capturing nature's diversity From Heteroaromatic Acids and Imines to Azaspirocycles: Stereoselective Synthesis and 3D Shape Analysis Targeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug Discovery Ring-Expansion Approach to Medium-Sized Lactams and Analysis of Their Medicinal Lead-Like Properties.The 'rule of three' for fragment-based drug discovery: where are we now?Diversity-oriented synthesis: producing chemical tools for dissecting biology.Fragment-based screening by protein crystallography: successes and pitfalls.A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds.Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.Weak affinity chromatography for evaluation of stereoisomers in early drug discovery.Translational synthetic chemistry.Synthesis of privileged scaffolds by using diversity-oriented synthesis.Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections.A three-stage biophysical screening cascade for fragment-based drug discovery.2-(Aryl-sulfonyl)oxetanes as designer 3-dimensional fragments for fragment screening: synthesis and strategies for functionalisation.Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams.Biofragments: an approach towards predicting protein function using biologically related fragments and its application to Mycobacterium tuberculosis CYP126.Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery.Diversity-oriented synthesis as a tool for chemical genetics.Medicinal chemistry for 2020 Facile access to a heterocyclic, sp(3)-rich chemical scaffold via a tandem condensation/intramolecular nitrone-alkene [3+2] cycloaddition strategy.State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.A one-pot, three-step process for the diastereoselective synthesis of aminobicyclo[4.3.0]nonanes using consecutive palladium(II)- and ruthenium(II)-catalysis.Partially Saturated Bicyclic Heteroaromatics as an sp(3) -Enriched Fragment Collection.A Tryptoline Ring-Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine.Divergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives.Fast & easy preparation of 3D scaffolds from methyl benzoate by a diversity oriented synthesis strategy based on Diels-Alder and ene-reactions.Macrocycles in new drug discovery.Synthesis of Spirocyclic Indolenines.Critical Evaluation of Native Electrospray Ionization Mass Spectrometry for Fragment-Based Screening.Modular Bi-Directional One-Pot Strategies for the Diastereoselective Synthesis of Structurally Diverse Collections of Constrained β-Carboline-Benzoxazepines.Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β Catalyst-Driven Scaffold Diversity: Selective Synthesis of Spirocycles, Carbazoles and Quinolines from Indolyl Ynones.Palladium-Catalyzed Directed C(sp(3))-H Arylation of Saturated Heterocycles at C-3 Using a Concise Optimization Approach A simple fragment of cyclic acyldepsipeptides is necessary and sufficient for ClpP activation and antibacterial activity Increasing the coverage of medicinal chemistry-relevant space in commercial fragments screening.Control of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group.

P2860

Q26829081-005B5C6E-6E07-4BE6-B893-400DEDE4F44F Q27678245-35A69A23-45C6-45C3-90BE-D95083F0897F Q27683610-739F9C99-9D02-4FA9-A985-D15C60768834 Q28546640-D7BAB7B9-BF84-4368-B82B-70EC705BD9F6 Q28821526-09663BDC-9B19-4E5B-B4E9-7650FBA3F394 Q30390894-CFB34A1D-3CC2-4A66-8909-68F1B1AEAA76 Q30490492-6DAA82C5-A25F-4868-9571-D8244CECBBCA Q31123058-3DCF2E32-2935-482F-A3F6-65B507094020 Q34227440-F7170B71-F106-41CD-97FB-0BE8A383000D Q34314898-99550478-00F5-4D9D-8300-38A312C7DED8 Q34378812-B96BE639-F844-41D1-A6E0-B397FD26192E Q34481459-CDCF6C3F-70D6-4381-99C0-3003600FFCFD Q34616425-47EF9E80-F4C8-4CE4-B83E-2803E7B570D8 Q34626958-4E411CF7-E36F-46D1-AE04-1C9E7129BACA Q34628172-F46A8042-2495-4B0D-AB5D-8C8D04370EED Q34880037-98DB850F-A372-484E-9381-D5F2EB7E2DF4 Q35025905-F13FD975-61EF-4396-A3B9-A999E3BD2452 Q35029400-D5AE7602-355A-45C3-8CFD-B05367BECB7F Q35079786-21914C53-D6E1-41C5-AB8C-636FF63DF76F Q35134065-C4D16BE9-2472-4DD3-A4F8-9218DB212635 Q35181268-A7F3A82C-4B2E-451B-9ED3-D4215423A79A Q35333752-38056DF2-AB26-4746-939E-C74B635BCB94 Q35593223-CC8F9EB4-195E-42E4-B249-213845AA07E8 Q35690007-62B2EDF7-6D79-4C93-AA44-6E32669289CC Q35738960-56CEA105-9201-4ED8-9E7B-420D986D5112 Q35942433-D82A349D-98BD-4030-B3BE-8CAB4D34A6CD Q36123327-4C2ADC7A-610E-4B16-9F21-A57B6C07E8EB Q36207545-3AE7ABDB-149E-4DBB-A77F-D2779AD73D43 Q36225570-E88C6C54-7E1C-4890-A36D-E47CE97D93FC Q36412099-8AE6902C-7337-4949-B189-9E5C2E6E2274 Q38031632-FEF18419-1B1B-48F5-9F6B-4D70EEB6B384 Q38667646-17100DB7-FCAA-4495-B486-05BA61EFF5F9 Q38724133-68C593B4-8970-48D4-9211-D6269BC6CEAE Q40108714-F37167B4-6579-4ADD-A6D0-81F90C81DC1F Q41063986-EE83CADD-10F1-4502-BF26-14C4CDDC2E84 Q41607485-7A205097-B42F-4338-A2C0-3E23A0CBA5B2 Q41763219-9138CF52-C1D5-455D-BA3C-B2D874794180 Q41862168-D9F848E0-D3DC-40A5-BA3C-933AE7179EF4 Q41896284-651EB81E-023F-4BDF-A745-2BBD57A8B3E7 Q41966027-A5FC35DC-92B4-48F3-8C7D-AF2CE6B8FC7A

P2860

Route to three-dimensional fragments using diversity-oriented synthesis.

http://www.wikidata.org/entity/Q33868796

description

2011 nî lūn-bûn

@nan

2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Route to three-dimensional fragments using diversity-oriented synthesis.

@ast

Route to three-dimensional fragments using diversity-oriented synthesis.

@en

type

label

Route to three-dimensional fragments using diversity-oriented synthesis.

@ast

Route to three-dimensional fragments using diversity-oriented synthesis.

@en

prefLabel

Route to three-dimensional fragments using diversity-oriented synthesis.

@ast

Route to three-dimensional fragments using diversity-oriented synthesis.

@en

P1433

Q33868796-19644FEB-A9D1-4695-ACE9-52C20DA3CD64

P1476

Q33868796-86301601-5C81-4E8E-A406-C8C56CE2E176

P2093

Q33868796-0B235A7D-B03B-485D-9F58-91F883F2F970

Q33868796-1E722F84-78AD-428F-859F-09225E87A92C

Q33868796-57CEAB9F-7CB5-453E-A6E5-957A63D77688

Q33868796-612C3401-80E3-401F-8151-E0FC910AB8E3

Q33868796-81363FC6-E46A-4584-B3E9-D53912799107

Q33868796-A97B38AD-74F3-48A3-AADE-55B0A9EA2637

Q33868796-B4B061BF-BF10-41E7-8A00-F9A4AACDE532

P2860

Q33868796-0887D017-23DC-429B-AA76-C82ECA87F5D6

Q33868796-0D0BFD11-E61A-445C-AF7F-89174FFD6123

Q33868796-0DA05A8B-04A6-4190-B040-8748BDD5B723

Q33868796-1503B8F8-D85C-4497-A33B-98F55DB7865E

Q33868796-1EEF132F-5183-4E8C-9D64-DF9604D0EA18

Q33868796-22A6C61F-DA2C-46E1-805A-7E5F694D446C

Q33868796-2609DA17-21EE-49DF-8AC2-3E24B12A7B13

Q33868796-2687094C-F14D-44DE-AABA-BBBCE6B10A16

Q33868796-41815247-C302-4B42-A98F-73D94BB3FE52

Q33868796-4BC2BE6A-0C43-46B1-82CC-915585D4642D

P304

Q33868796-ED8EF00E-18E8-4D1B-82C6-AC37F017E2FD

P31

Q33868796-8DF68C28-2438-4848-9647-C41D3B1E58B6

P356

Q33868796-D213FAA9-64E5-42E2-91C8-4C77AF19F375

P407

Q33868796-C970B864-C35F-489C-9AB1-5F214FB57FCE

P433

Q33868796-0907BDA5-C8DF-45D7-8BEA-4E07E7647922

P478

Q33868796-4C0AFE75-3DB9-4023-9C88-40A8308B4335

P577

Q33868796-C93C7450-7D06-44E4-A146-FD606AEDFDD5

P5875

Q33868796-BCD41C17-6E45-476A-AC59-E42B0538F275

P698

Q33868796-AA7618C1-A6D0-4F9F-B606-27C9659916F7

P932

Q33868796-9C0805FF-D99B-449B-BED6-3DBCB53A4240

P356

PNAS.1015271108

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Route to three-dimensional fragments using diversity-oriented synthesis.

@en

P2093

Alex Ramek

http://www.w3.org/2001/XMLSchema#string

Alvin W Hung

http://www.w3.org/2001/XMLSchema#string

Damian W Young

http://www.w3.org/2001/XMLSchema#string

J Anthony Wilson

http://www.w3.org/2001/XMLSchema#string

Paul A Clemons

http://www.w3.org/2001/XMLSchema#string

Taner Kaya

http://www.w3.org/2001/XMLSchema#string

Yikai Wang

http://www.w3.org/2001/XMLSchema#string

P2860

A small molecule that binds Hedgehog and blocks its signaling in human cells

Recent developments in fragment-based drug discovery

ZINC--a free database of commercially available compounds for virtual screening

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase

Target-oriented and diversity-oriented organic synthesis in drug discovery

A planning strategy for diversity-oriented synthesis

Fragment-based lead discovery: leads by design

Small molecules: the missing link in the central dogma

Virtual exploration of the chemical universe up to 11 atoms of C, N, O, F: assembly of 26.4 million structures (110.9 million stereoisomers) and analysis for new ring systems, stereochemistry, physicochemical properties, compound classes, and drug d

Towards the optimal screening collection: a synthesis strategy

P304

6799-6804

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.1015271108

http://www.w3.org/2001/XMLSchema#string

P407

P433

17

http://www.w3.org/2001/XMLSchema#string

P478

108

http://www.w3.org/2001/XMLSchema#string

P577

2011-04-11T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51041602

http://www.w3.org/2001/XMLSchema#string

P698

21482811

http://www.w3.org/2001/XMLSchema#string

P932

3084099

http://www.w3.org/2001/XMLSchema#string