Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion. - Wikidata - wikimedia - TriplyDB

Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion.

Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion.

http://www.wikidata.org/entity/Q33870552

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Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches Ethanol enhances the interaction of breast cancer cells over-expressing ErbB2 with fibronectin Etk/Bmx regulates proteinase-activated-receptor1 (PAR1) in breast cancer invasion: signaling partners, hierarchy and physiological significance Comparative expression study of the endo-G protein coupled receptor (GPCR) repertoire in human glioblastoma cancer stem-like cells, U87-MG cells and non malignant cells of neural origin unveils new potential therapeutic targets The Transmodulation of HER2 and EGFR by Substance P in Breast Cancer Cells Requires c-Src and Metalloproteinase Activation Transactivation of EGFR/PI3K/Akt involved in ATP-induced inflammatory protein expression and cell motility Lgr5 over-expression is positively related to the tumor progression and HER2 expression in stage pTNM IV colorectal cancer PRSS3 is a prognostic marker in invasive ductal carcinoma of the breast.Tissue factor and PAR2 signaling in the tumor microenvironment Investigating AP-2 and YY1 protein expression as a cause of high HER2 gene transcription in breast cancers with discordant HER2 gene amplification.Promotion of human trophoblasts invasion by gonadotropin-releasing hormone (GnRH) I and GnRH II via distinct signaling pathways.Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha.Evidence for tissue factor phosphorylation and its correlation with protease-activated receptor expression and the prognosis of primary breast cancer.GPCRs and cancer N-linked glycosylation of protease-activated receptor-1 second extracellular loop: a critical determinant for ligand-induced receptor activation and internalization Identification of a metalloprotease-chemokine signaling system in the ovarian cancer microenvironment: implications for antiangiogenic therapy.Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109 Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models.Constructing the HBV-human protein interaction network to understand the relationship between HBV and hepatocellular carcinoma.Par genes: molecular probes to pathological assessment in breast cancer progression Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17.Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells.Suppression of Heregulin-β1/HER2-Modulated Invasive and Aggressive Phenotype of Breast Carcinoma by Pterostilbene via Inhibition of Matrix Metalloproteinase-9, p38 Kinase Cascade and Akt Activation.Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells G Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation.A Her2-let-7-β2-AR circuit affects prognosis in patients with Her2-positive breast cancer.Expression of MMP-1/PAR-1 and patterns of invasion in oral squamous cell carcinoma as potential prognostic markers Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins.Kallikrein 6 is a novel molecular trigger of reactive astrogliosis.Matrix metalloprotease-1a promotes tumorigenesis and metastasis.Protease-activated receptors (PARs)--biology and role in cancer invasion and metastasis.Clinical significance and novel mechanism of action of kallikrein 6 in glioblastoma.STAT3-mediated coincidence detection regulates noncanonical immediate early gene induction.Thrombin stimulation of inflammatory breast cancer cells leads to aggressiveness via the EGFR-PAR1-Pak1 pathway Caveolae are required for protease-selective signaling by protease-activated receptor-1.PAR1 is selectively over expressed in high grade breast cancer patients: a cohort study Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling.

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P2860

Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion.

http://www.wikidata.org/entity/Q33870552

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2008 nî lūn-bûn

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TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

Thrombin receptor overexpression in malignant and physiological invasion processes

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization.

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

EGFR and cancer prognosis.

Biology of HER2 and its importance in breast cancer.

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