The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents
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The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.Janus Compounds, 5-Chloro-N⁴-methyl-N⁴-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects.Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based DesignDiscovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.Antiangiogenesis and vascular disrupting agents in cancer: circumventing resistance and augmenting their therapeutic utility.Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells.Indole molecules as inhibitors of tubulin polymerization: potential new anticancer agents, an update (2013-2015).Design, Synthesis and Molecular Docking Studies of Novel Indole-Pyrimidine Hybrids as Tubulin Polymerization Inhibitors.AG488 as a therapy against gliomas.Structure based drug design and in vitro metabolism study: Discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent.Design, synthesis, and screening of ortho-amino thiophene carboxamide derivatives on hepatocellular carcinomaas VEGFR-2InhibitorsEnaminonitrile as Building Block in Heterocyclic Synthesis: Synthesis of Novel 4H-Furo[2,3-d][1,3]oxazin-4-one and Furo[2,3-d]pyrimidin-4(3H)-one Derivatives
P2860
Q35539229-68155601-27A5-4829-A762-6A50E24F8143Q36213315-B4867886-2FAD-47E3-A1E2-12E319A240C9Q36502953-9BE41343-826D-4C3A-9174-5980D1EBD9D4Q38728583-E0C6C669-3638-40FF-83F0-E1626960F0AEQ38757723-34566F5C-2F05-4601-9ED7-A1254B32B39CQ38769177-D2BAF59F-F442-4CC0-A37C-D6A39B6750B6Q38835979-0C939563-6DF0-4435-8A25-8688971F2ACEQ38852745-612DCA84-183A-46B5-A7C6-309AF63ED0E9Q42700872-48DFD275-D0CD-488B-AAE2-5DD7D5C9B6C2Q52719383-010A0038-F2F0-4A4C-94DC-F4C37540DD9DQ58759036-C5818933-AF6C-44D8-AEE2-52E1F32CC268Q59145892-A6F3EBBF-62CC-49D0-BD00-B878C116FBDC
P2860
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents
description
2014 nî lūn-bûn
@nan
2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
The design and discovery of wa ...... ule targeting antitumor agents
@ast
The design and discovery of wa ...... ule targeting antitumor agents
@en
type
label
The design and discovery of wa ...... ule targeting antitumor agents
@ast
The design and discovery of wa ...... ule targeting antitumor agents
@en
prefLabel
The design and discovery of wa ...... ule targeting antitumor agents
@ast
The design and discovery of wa ...... ule targeting antitumor agents
@en
P2093
P2860
P1476
The design and discovery of wa ...... ule targeting antitumor agents
@en
P2093
Aleem Gangjee
Anja Bastian
Bryan C Disch
Cristina C Rohena
Ernest Hamel
Jessica E Thorpe
Lora C Bailey-Downs
Michael Ihnat
Susan L Mooberry
P2860
P304
P356
10.1016/J.BMC.2014.04.049
P407
P577
2014-05-14T00:00:00Z