Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia - Wikidata - wikimedia - TriplyDB

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

http://www.wikidata.org/entity/Q33874305

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The role of oxidative stress in Parkinson's disease Emerging preclinical pharmacological targets for Parkinson's disease Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes Mechanism of Anti-α-Synuclein Immunotherapy The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases Immunotherapy in Parkinson's Disease: Micromanaging Alpha-Synuclein Aggregation Oxidative stress and Parkinson's disease Glia and alpha-synuclein in neurodegeneration: A complex interaction The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?M1 and M2 immune activation in Parkinson's Disease: Foe and ally?Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Protective Microglia and Their Regulation in Parkinson's Disease Seeking a mechanism for the toxicity of oligomeric α-synuclein Mechanisms of long-term cognitive dysfunction of sepsis: from blood-borne leukocytes to glial cells Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.New insights on NOX enzymes in the central nervous system.Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity.A Decade of Research on TLR2 Discovering Its Pivotal Role in Glial Activation and Neuroinflammation in Neurodegenerative Diseases.Hippocampal proliferation is increased in presymptomatic Parkinson's disease and due to microglia.Transglutaminase 2 exacerbates α-synuclein toxicity in mice and yeast Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients.Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.The role of Galectin-3 in α-synuclein-induced microglial activation.Alpha-synuclein function and dysfunction on cellular membranes.Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses.Combined effect of TLR2 gene polymorphism and early life stress on the age at onset of bipolar disorders.α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation.Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease.Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease.Toll-like receptor expression in the blood and brain of patients and a mouse model of Parkinson's disease Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein.Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes.Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease The Interplay between Alpha-Synuclein Clearance and Spreading Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders.Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia.Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.

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Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

http://www.wikidata.org/entity/Q33874305

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2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013 թվականի հունվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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Neuron-released oligomeric α-s ...... acrine activation of microglia

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Neuron-released oligomeric α-s ...... acrine activation of microglia

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Neuron-released oligomeric α-s ...... acrine activation of microglia

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Neuron-released oligomeric α-s ...... acrine activation of microglia

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Changyoun Kim

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Daehee Hwang

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Dong-Hwan Ho

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He-Jin Lee

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Ji-Eun Suk

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Junghee Kang

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Sarah Michael

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Seung-Jae Lee

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Sung Joong Lee

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Sungyong You

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P2860

Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis

MyD88 deficiency ameliorates β-amyloidosis in an animal model of Alzheimer's disease

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product

Assessment of α-synuclein secretion in mouse and human brain parenchyma

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L.

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10.1038/NCOMMS2534

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4

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Eliezer Masliah

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2013-01-01T00:00:00Z

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235797068

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1003907929

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Toll-like receptor

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