Pig-n, a mammalian homologue of yeast Mcd4p, is involved in transferring phosphoethanolamine to the first mannose of the glycosylphosphatidylinositol.
about
Human Smp3p adds a fourth mannose to yeast and human glycosylphosphatidylinositol precursors in vivoPIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER.Biosynthesis and deficiencies of glycosylphosphatidylinositolHuman genetic disorders involving glycosylphosphatidylinositol (GPI) anchors and glycosphingolipids (GSL)Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I.Glycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p-deficient yeast suggest a branched pathway and implicate gpi13p in phosphoethanolamine transfer to the third mannose.ATP uptake in the Golgi and extracellular release require Mcd4 protein and the vacuolar H+-ATPase.A genomic study of the bipolar bud site selection pattern in Saccharomyces cerevisiae.PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor.The essential Smp3 protein is required for addition of the side-branching fourth mannose during assembly of yeast glycosylphosphatidylinositols.Ethanolaminephosphate side chain added to glycosylphosphatidylinositol (GPI) anchor by mcd4p is required for ceramide remodeling and forward transport of GPI proteins from endoplasmic reticulum to Golgi.Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositolConserved core structure and active site residues in alkaline phosphatase superfamily enzymes.A homozygous PIGN missense mutation in Soft-Coated Wheaten Terriers with a canine paroxysmal dyskinesia.PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features.Analysis of exome data for 4293 trios suggests GPI-anchor biogenesis defects are a rare cause of developmental disorders.Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal Pathogen Candida albicans.Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling.Regulation of the yeast EKI1-encoded ethanolamine kinase by inositol and choline.Mutational analysis of the glycosylphosphatidylinositol (GPI) anchor pathway demonstrates that GPI-anchored proteins are required for cell wall biogenesis and normal hyphal growth in Neurospora crassa.A screen for deficiencies in GPI-anchorage of wall glycoproteins in yeast.Autophagy competes for a common phosphatidylethanolamine pool with major cellular PE-consuming pathways in Saccharomyces cerevisiae.Simulation and estimation of gene number in a biological pathway using almost complete saturation mutagenesis screening of haploid mouse cells.E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesisThe phenotype of a germline mutation in PIGA: the gene somatically mutated in paroxysmal nocturnal hemoglobinuria.Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly.Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis.Phosphatidylethanolamine Metabolism in Health and Disease.Thematic review series: lipid posttranslational modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids.Trypanosome glycosylphosphatidylinositol biosynthesis.A complex game of hide and seek: the search for new antifungalsPeroxisome dependency of alkyl-containing GPI-anchor biosynthesis in the endoplasmic reticulum.A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO.GPI transamidase and GPI anchored proteins: oncogenes and biomarkers for cancer.The GPI anchor pathway: a promising antifungal target?Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins.New insights into the functions of PIGF, a protein involved in the ethanolamine phosphate transfer steps of glycosylphosphatidylinositol biosynthesis.Breast cancer cells adapt to metabolic stress by increasing ethanolamine phospholipid synthesis and CTP:ethanolaminephosphate cytidylyltransferase-Pcyt2 activity.Defective lipid remodeling of GPI anchors in peroxisomal disorders, Zellweger syndrome, and rhizomelic chondrodysplasia punctata.Mechanism for release of alkaline phosphatase caused by glycosylphosphatidylinositol deficiency in patients with hyperphosphatasia mental retardation syndrome.
P2860
Q24297382-CA26FFD5-F1EA-4E85-BFB1-EFAE6175618EQ24540354-935B974E-5B27-44DC-94A3-55F349898F68Q26998348-821F3D9F-401D-4DF1-A34C-960E25634969Q27021835-105FD126-0090-456A-B577-F1B91E09DF93Q27933583-AC27C0EA-782E-408E-ACA1-0A4072ADA0E2Q27934630-E10C27BD-35DD-458C-92F2-914CBE542C41Q27935577-3C157509-5577-42A0-A4D6-586DE7C33823Q27937139-BEB310FD-5088-4A55-BF83-51D4DDDE54A2Q27937797-8272AD61-667E-41C8-9485-A18F10E3979CQ27939589-4808555A-546B-46E4-88F6-2614DF1B18C3Q27939592-ABD7E718-52B8-486F-B81F-8EF143FBE152Q28511718-B30C4961-BA93-47C5-B160-E588B6C098FDQ30779887-2C117BA9-77B2-4D96-A2BB-4E3E94FED249Q30835408-7A543F31-CF5F-420A-849E-E68AB9265AB8Q33728184-2312698E-AD5D-4EAB-98F1-3FD618F3C2EEQ33815229-6A47F483-DFD6-4225-8015-0442D64A7DD5Q33930289-CE84F41E-D50E-42BB-B5E0-430D6E48257AQ34045400-96082F77-C24D-4164-B1F5-6DD10132D811Q34327422-B477F14E-9D1D-4138-BE11-D5BBB0130058Q34442112-3F22B2C0-9D31-4DDD-BF7C-916269D6E459Q34631992-76AD1EE4-3C12-4ECE-A995-74B25B0C8C72Q35050892-C2CAC84D-EAE0-477E-A650-BFAE1C886D48Q35445231-FA3D2B73-9895-4028-96D8-9265A8159115Q35689250-D7D02586-8B02-47CC-85C5-CB66FEEC11BBQ35748335-CB913145-7D7D-4FDB-A25F-C633183C82A5Q36425692-9822108A-7D1E-4724-8BF7-8484ADC4B675Q36539252-C978AD58-8FC3-40F7-B61A-044ADCB33EF4Q36652965-CC1D08E2-F9A0-4D69-826F-0087C0934058Q36759924-AB6B5AD3-AE4B-4272-916A-CD9A20E5AC27Q37327780-52308C73-D925-43F5-A124-4DCF41985DA5Q37344546-2DF2FF70-423F-4455-95C0-ABFD11B8FA5EQ37394442-BEEFE25C-E208-46D4-BE2A-EB4F2727A345Q37488338-E0A7B76B-42BA-44DA-B8C6-0C308F138A26Q38131553-9FEF8122-CA9E-45CD-81A2-C87DED0CCECDQ38832565-E389018A-B155-437F-AC01-3A679556E8A9Q38864129-5D2B0534-CE3B-4A7C-974C-7767932133F7Q38970512-E6C60E66-EDA3-46E5-8E82-AA73691D45DBQ39395943-3FF7D590-EFBC-4402-8C91-6E07550CDE4CQ39410645-FB09B9E3-3374-4AF0-B014-53C503DB622FQ41963774-D5F5471C-0219-4FBE-8829-038D66AE0BA5
P2860
Pig-n, a mammalian homologue of yeast Mcd4p, is involved in transferring phosphoethanolamine to the first mannose of the glycosylphosphatidylinositol.
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Pig-n, a mammalian homologue o ...... glycosylphosphatidylinositol.
@ast
Pig-n, a mammalian homologue o ...... glycosylphosphatidylinositol.
@en
type
label
Pig-n, a mammalian homologue o ...... glycosylphosphatidylinositol.
@ast
Pig-n, a mammalian homologue o ...... glycosylphosphatidylinositol.
@en
prefLabel
Pig-n, a mammalian homologue o ...... glycosylphosphatidylinositol.
@ast
Pig-n, a mammalian homologue o ...... glycosylphosphatidylinositol.
@en
P2093
P2860
P356
P1476
Pig-n, a mammalian homologue o ...... glycosylphosphatidylinositol.
@en
P2093
P2860
P304
35099-35106
P356
10.1074/JBC.274.49.35099
P407
P577
1999-12-01T00:00:00Z