Phosphorylation of activation functions AF-1 and AF-2 of RAR alpha and RAR gamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment.
about
A retinoic acid receptor RARα pool present in membrane lipid rafts forms complexes with G protein αQ to activate p38MAPKPhosphorylation by p38MAPK and recruitment of SUG-1 are required for RA-induced RAR gamma degradation and transactivation.Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signalingLoss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiationA phosphorylation defective retinoic acid receptor mutant mimics the effects of retinoic acid on EGFR mediated AP-1 expression and cancer cell proliferation.Coordinate regulation of RARgamma2, TBP, and TAFII135 by targeted proteolysis during retinoic acid-induced differentiation of F9 embryonal carcinoma cellsA coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promotersTranscriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cellsPeroxisome proliferator-activated receptor delta (PPARdelta )-mediated regulation of preadipocyte proliferation and gene expression is dependent on cAMP signaling.Nerve growth factor activates the RARbeta2 promoter by a Ras-dependent mechanism.Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemiaIn vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia.Modulating nuclear receptor function: may the phos be with youRetinoic acid receptor alpha1 variants, RARalpha1DeltaB and RARalpha1DeltaBC, define a new class of nuclear receptor isoforms.Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXRalpha phosphorylation.Retinoic acid receptor alpha (RAralpha) Mutations in Human Leukemia.Function of RARalpha during the maturation of neutrophils.Phosphorylation by PKA potentiates retinoic acid receptor alpha activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7.Genome-wide in silico identification of new conserved and functional retinoic acid receptor response elements (direct repeats separated by 5 bp)Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activatorsVitamin A and retinoid signaling: genomic and nongenomic effects.Ligand-dependent activation of transcription in vitro by retinoic acid receptor alpha/retinoid X receptor alpha heterodimers that mimics transactivation by retinoids in vivoA unique cytoplasmic localization of retinoic acid receptor-gamma and its regulationsNuclear and extranuclear effects of vitamin A.Association with Ets-1 causes ligand- and AF2-independent activation of nuclear receptors.Retinoic acid treatment and cell aggregation independently regulate alternative splicing in P19 cells during neural differentiation.Retinoid-suppressed phosphorylation of RARalpha mediates the differentiation pathway of osteosarcoma cells.Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAILPML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiationRetinoid-induced G1 arrest and differentiation activation are associated with a switch to cyclin-dependent kinase-activating kinase hypophosphorylation of retinoic acid receptor alpha.4HPR triggers apoptosis but not differentiation in retinoid sensitive and resistant human embryonal carcinoma cells through an RARgamma independent pathway.Mutations in the activation function-2 core domain of steroidogenic factor-1 dominantly suppresses PKA-dependent transactivation of the bovine CYP17 gene.Synergistic transcriptional activation of the mouse urokinase plasminogen activator (uPA) gene and of its enhancer activator protein 1 (AP1) site by cAMP and retinoic acid.Regulation of retinoic acid receptor alpha by protein kinase C in B16 mouse melanoma cells.The phosphorylation site located in the A region of retinoic X receptor alpha is required for the antiproliferative effect of retinoic acid (RA) and the activation of RA target genes in F9 cells.The AF-1 and AF-2 domains of RAR gamma 2 and RXR alpha cooperate for triggering the transactivation and the degradation of RAR gamma 2/RXR alpha heterodimers.Teaching resources. Nuclear receptors.Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia.Retinoic acid receptors interact physically and functionally with the T:G mismatch-specific thymine-DNA glycosylase.Multiple regulatory elements in the murine stromelysin-3 promoter. Evidence for direct control by CCAAT/enhancer-binding protein beta and thyroid and retinoid receptors.
P2860
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P2860
Phosphorylation of activation functions AF-1 and AF-2 of RAR alpha and RAR gamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment.
description
1997 nî lūn-bûn
@nan
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Phosphorylation of activation ...... inoic acid and cAMP treatment.
@ast
Phosphorylation of activation ...... inoic acid and cAMP treatment.
@en
type
label
Phosphorylation of activation ...... inoic acid and cAMP treatment.
@ast
Phosphorylation of activation ...... inoic acid and cAMP treatment.
@en
prefLabel
Phosphorylation of activation ...... inoic acid and cAMP treatment.
@ast
Phosphorylation of activation ...... inoic acid and cAMP treatment.
@en
P2093
P2860
P356
P1433
P1476
Phosphorylation of activation ...... inoic acid and cAMP treatment.
@en
P2093
C Rochette-Egly
J L Plassat
P2860
P304
P356
10.1093/EMBOJ/16.21.6452
P407
P577
1997-11-01T00:00:00Z