Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach.
about
Molecular Biology and Clinical Mitigation of Cancer Treatment-Induced NeuropathyAxonal Transport and Neurodegeneration: How Marine Drugs Can Be Used for the Development of TherapeuticsZampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubulesDocetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicityModulation of microtubule interprotofilament interactions by modified taxanesCyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site.Dissecting paclitaxel-microtubule association: quantitative assessment of the 2'-OH groupRecent progress with microtubule stabilizers: new compounds, binding modes and cellular activities.Structural Basis of Microtubule Stabilization by Discodermolide.Experimental and computational study of the interaction of novel colchicinoids with a recombinant human αI/βI-tubulin heterodimer.Investigating Protein-Ligand Interactions by Solution Nuclear Magnetic Resonance Spectroscopy.Screening Anti-Cancer Drugs against Tubulin using Catch-and-Release Electrospray Ionization Mass Spectrometry.Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones).Structural investigations into the binding mode of novel neolignans Cmp10 and Cmp19 microtubule stabilizers byin silicomolecular docking, molecular dynamics, and binding free energy calculationsNMR studies on carbohydrate interactions with DC-SIGN towards a quantitative STD analysis
P2860
Q26747796-41F4C8D2-7EED-463C-AF7B-CD3C2EF0C0BDQ28079729-4C56C574-148A-42A2-BD64-7C311ACD7042Q30518054-44715172-70E0-4850-B9DA-BB88B9BB5D76Q34394402-F5757C95-1F3F-4BC7-92E7-1ECBCF6A9B28Q35627768-3A34BCA8-B44F-4128-A803-E1F249563844Q35664859-7E747275-DA01-47C0-B3F7-555A6A59DB0DQ36936950-279DA846-64B2-4BC9-B97F-6380BC5FE52AQ38183686-F79B62C4-A427-4F71-AB30-0EDC6B767AFEQ38957234-62EE35D2-1D1D-4B07-83AA-0A7A705D6A32Q44423122-A912130C-FF29-4BAC-A9C8-250C845345B8Q47218921-C4691B06-AE9B-44CA-B200-1C8D8602E74AQ48858919-E009DC29-C570-4CA5-AC98-20B7F36FB989Q51569908-E20B5036-7C5F-407C-A314-A62B2AEBB3F5Q57781260-679F2BD2-B937-4E8F-80A7-ECAF33324E3DQ58328189-BF3EE35B-9178-4B47-8E48-44D461543058
P2860
Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Insights into the interaction ...... MR and computational approach.
@ast
Insights into the interaction ...... MR and computational approach.
@en
type
label
Insights into the interaction ...... MR and computational approach.
@ast
Insights into the interaction ...... MR and computational approach.
@en
prefLabel
Insights into the interaction ...... MR and computational approach.
@ast
Insights into the interaction ...... MR and computational approach.
@en
P2093
P356
P1433
P1476
Insights into the interaction ...... MR and computational approach.
@en
P2093
Angeles Canales
Chiara Trigili
Claire Coderch
Ian Paterson
J Fernando Díaz
Javier Rodríguez-Salarichs
Jesús Jiménez-Barbero
José Manuel Andreu
Lidia Nieto
P304
P356
10.1021/CB200099U
P577
2011-05-13T00:00:00Z