Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6).
about
De novo pathogenic SCN8A mutation identified by whole-genome sequencing of a family quartet affected by infantile epileptic encephalopathy and SUDEPDe novo gain-of-function and loss-of-function mutations of SCN8A in patients with intellectual disabilities and epilepsyAn Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.Prioritizing the development of mouse models for childhood brain disordersDeletion of the mouse homolog of KCNAB2, a gene linked to monosomy 1p36, results in associative memory impairments and amygdala hyperexcitability.Analysis of the mouse mutant Cloth-ears shows a role for the voltage-gated sodium channel Scn8a in peripheral neural hearing loss.Heterozygous mutations of the voltage-gated sodium channel SCN8A are associated with spike-wave discharges and absence epilepsy in mice.Convulsive seizures and SUDEP in a mouse model of SCN8A epileptic encephalopathy.Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.Dysfunction of the Scn8a voltage-gated sodium channel alters sleep architecture, reduces diurnal corticosterone levels, and enhances spatial memory.Sodium channel SCN8A (Nav1.6): properties and de novo mutations in epileptic encephalopathy and intellectual disability.Inherited neuronal ion channelopathies: new windows on complex neurological diseases.Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expressionRbfox proteins regulate alternative splicing of neuronal sodium channel SCN8AImatinib treatment reduces brain injury in a murine model of traumatic brain injuryDeletion of fibroblast growth factor 22 (FGF22) causes a depression-like phenotype in adult mice.Mice with an NaV1.4 sodium channel null allele have latent myasthenia, without susceptibility to periodic paralysis.Single amino acid deletion in transmembrane segment D4S6 of sodium channel Scn8a (Nav1.6) in a mouse mutant with a chronic movement disorder.Current Perspectives in Autism Spectrum Disorder: From Genes to Therapy.Sodium channel blockers for the treatment of neuropathic pain.Scn8a voltage-gated sodium channel mutation alters seizure and anxiety responses to acute stress.Recurrent and Non-Recurrent Mutations of SCN8A in Epileptic Encephalopathy.Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a.Loss-of-function variants of SCN8A in intellectual disability without seizures.Neurologic adverse effects of ranolazine in an elderly patient with renal impairment.The L-type voltage-gated calcium channel CaV1.2 mediates fear extinction and modulates synaptic tone in the lateral amygdala.Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice.Genetic polymorphisms in the SCN8A gene are associated with suicidal behavior in psychiatric disorders in the Chinese population.
P2860
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P2860
Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6).
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Exaggerated emotional behavior ...... sodium channel Scn8a (Nav1.6).
@ast
Exaggerated emotional behavior ...... sodium channel Scn8a (Nav1.6).
@en
type
label
Exaggerated emotional behavior ...... sodium channel Scn8a (Nav1.6).
@ast
Exaggerated emotional behavior ...... sodium channel Scn8a (Nav1.6).
@en
prefLabel
Exaggerated emotional behavior ...... sodium channel Scn8a (Nav1.6).
@ast
Exaggerated emotional behavior ...... sodium channel Scn8a (Nav1.6).
@en
P2093
P2860
P1476
Exaggerated emotional behavior ...... sodium channel Scn8a (Nav1.6).
@en
P2093
B C McKinney
G G Murphy
M H Meisler
P2860
P304
P356
10.1111/J.1601-183X.2008.00399.X
P407
P577
2008-03-21T00:00:00Z