High affinity, developability and functional size: the holy grail of combinatorial antibody library generation.
about
Engineered IgG1-Fc--one fragment to bind them allRationalization and Design of the Complementarity Determining Region Sequences in an Antibody-Antigen Recognition InterfaceOrigins of specificity and affinity in antibody-protein interactionsBacterial cytoplasm as an effective cell compartment for producing functional VHH-based affinity reagents and Camelidae IgG-like recombinant antibodiesHapten mediated display and pairing of recombinant antibodies accelerates assay assembly for biothreat countermeasuresDesign of peptide affinity ligands for S-protein: a comparison of combinatorial and de novo design strategies.A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties.Ebolavirus nucleoprotein C-termini potently attract single domain antibodies enabling monoclonal affinity reagent sandwich assay (MARSA) formulation.ProxiMAX randomization: a new technology for non-degenerate saturation mutagenesis of contiguous codonsThe application of next generation sequencing to the understanding of antibody repertoires.A novel heavy domain antibody library with functionally optimized complementarity determining regions.In vitro Fab display: a cell-free system for IgG discoveryA highly functional synthetic phage display library containing over 40 billion human antibody clones.Development trends for generation of single-chain antibody fragments.Library construction, selection and modification strategies to generate therapeutic peptide-based modulators of protein-protein interactions.Progress in the development of immunoanalytical methods incorporating recombinant antibodies to small molecular weight biotoxins.Advances in phage display technology for drug discovery.Isolation and Characterization of a Monobody with a Fibronectin Domain III Scaffold That Specifically Binds EphA2.Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigensPreferential germline usage and VH/VL pairing observed in human antibodies selected by mRNA display.Construction of a Semisynthetic Human VH Single-Domain Antibody Library and Selection of Domain Antibodies against α-Crystalline of Mycobacterium tuberculosis.Directed evolution of human scFvs in DT40 cells.Discovery of high affinity anti-ricin antibodies by B cell receptor sequencing and by yeast display of combinatorial VH:VL libraries from immunized animals.Selection of Recombinant Human Antibodies.Library-based display technologies: where do we stand?Combinatorial antibody libraries: new advances, new immunological insights.Evolution of phage display technology: from discovery to application.Analysis of SIVmac Envelope-Specific Antibodies Selected Through Phage Display.High-Throughput IgG Conversion of Phage Displayed Fab Antibody Fragments by AmplYFast.Multivalent pIX phage display selects for distinct and improved antibody properties.The future of protein scaffolds as affinity reagents for purification.A novel screening method to assess developability of antibody-like molecules.Antibodies specific for nucleic acid modifications.Monoclonal antibodies protect from Staphylococcal Enterotoxin K (SEK) induced toxic shock and sepsis by USA300 Staphylococcus aureus.Molecular dynamics simulations and docking enable to explore the biophysical factors controlling the yields of engineered nanobodies.Early developability screen of therapeutic antibody candidates using Taylor dispersion analysis and UV area imaging detection.A mechanistic PK/PD model for two anti-IL13 antibodies explains the difference in total IL-13 accumulation observed in clinical studies.An automated immunoassay for early specificity profiling of antibodiesGeneration, Diversity Determination, and Application to Antibody Selection of a Human Naïve Fab Library.The clinical potential of circulating tumor cells; the need to incorporate a modern "immunological cocktail" in the assay.
P2860
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P2860
High affinity, developability and functional size: the holy grail of combinatorial antibody library generation.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
High affinity, developability ...... l antibody library generation.
@ast
High affinity, developability ...... l antibody library generation.
@en
type
label
High affinity, developability ...... l antibody library generation.
@ast
High affinity, developability ...... l antibody library generation.
@en
prefLabel
High affinity, developability ...... l antibody library generation.
@ast
High affinity, developability ...... l antibody library generation.
@en
P2093
P1433
P1476
High affinity, developability ...... al antibody library generation
@en
P2093
Dirk Ponsel
Julia Neugebauer
Kathrin Ladetzki-Baehs
Kathrin Tissot
P304
P356
10.3390/MOLECULES16053675
P407
P577
2011-05-03T00:00:00Z