PrlA4 prevents the rejection of signal sequence defective preproteins by stabilizing the SecA-SecY interaction during the initiation of translocation.
about
SecA, a remarkable nanomachineThe conformation of a signal peptide bound by Escherichia coli preprotein translocase SecAProtein targeting to the bacterial cytoplasmic membrane.Signal peptides are allosteric activators of the protein translocase.The PrlA and PrlG phenotypes are caused by a loosened association among the translocase SecYEG subunits.Escherichia coli translocase: the unravelling of a molecular machine.The SecYEG preprotein translocation channel is a conformationally dynamic and dimeric structureCritical regions of secM that control its translation and secretion and promote secretion-specific secA regulation.A novel class of secA alleles that exert a signal-sequence-dependent effect on protein export in Escherichia coli.Ring-like pore structures of SecA: implication for bacterial protein-conducting channels.Probing the SecYEG translocation pore size with preproteins conjugated with sizable rigid spherical molecules.A prl mutation in SecY suppresses secretion and virulence defects of Listeria monocytogenes secA2 mutantsDifferent modes of SecY-SecA interactions revealed by site-directed in vivo photo-cross-linking.Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelityThe bacterial Sec-translocase: structure and mechanism.Interactions that drive Sec-dependent bacterial protein transport.Assembly of the translocase motor onto the preprotein-conducting channel.Protein conducting channels-mechanisms, structures and applications.Investigating the SecY plug movement at the SecYEG translocation channel.Preprotein translocation by a hybrid translocase composed of Escherichia coli and Bacillus subtilis subunits.Projection structure and oligomeric properties of a bacterial core protein translocase.Dissociation of the dimeric SecA ATPase during protein translocation across the bacterial membrane.A SecE mutation that modulates SecY-SecE translocase assembly, identified as a specific suppressor of SecY defectsBiochemical characterization of a mutationally altered protein translocase: proton motive force stimulation of the initiation phase of translocation.Binding, activation and dissociation of the dimeric SecA ATPase at the dimeric SecYEG translocase.Unlocking the Bacterial SecY Translocon.Characterization of the Escherichia coli SecA signal peptide-binding site.Mapping of the SecA·SecY and SecA·SecG interfaces by site-directed in vivo photocross-linking.Immobilization of the plug domain inside the SecY channel allows unrestricted protein translocation.Membrane deinsertion of SecA underlying proton motive force-dependent stimulation of protein translocationYidC and SecYEG form a heterotetrameric protein translocation channel.Competitive binding of the SecA ATPase and ribosomes to the SecYEG translocon.Mapping the sites of interaction between SecY and SecE by cysteine scanning mutagenesis.The core of the bacterial translocase harbors a tilted transmembrane segment 3 of SecE.Kinetic analysis of the translocation of fluorescent precursor proteins into Escherichia coli membrane vesicles.Superactive SecY variants that fulfill the essential translocation function with a reduced cellular quantity.Defective translocation of a signal sequence mutant in a prlA4 suppressor strain of Escherichia coli.Direct demonstration of ATP-dependent release of SecA from a translocating preprotein by surface plasmon resonance.Two-stage binding of SecA to the bacterial translocon regulates ribosome-translocon interaction.Covalently dimerized SecA is functional in protein translocation.
P2860
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P2860
PrlA4 prevents the rejection of signal sequence defective preproteins by stabilizing the SecA-SecY interaction during the initiation of translocation.
description
1998 nî lūn-bûn
@nan
1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
PrlA4 prevents the rejection o ...... e initiation of translocation.
@ast
PrlA4 prevents the rejection o ...... e initiation of translocation.
@en
type
label
PrlA4 prevents the rejection o ...... e initiation of translocation.
@ast
PrlA4 prevents the rejection o ...... e initiation of translocation.
@en
prefLabel
PrlA4 prevents the rejection o ...... e initiation of translocation.
@ast
PrlA4 prevents the rejection o ...... e initiation of translocation.
@en
P2093
P2860
P356
P1433
P1476
PrlA4 prevents the rejection o ...... e initiation of translocation.
@en
P2093
A J Driessen
J P van der Wolk
T J Silhavy
P2860
P304
P356
10.1093/EMBOJ/17.13.3631
P407
P577
1998-07-01T00:00:00Z