Structural analysis of the GAP-related domain from neurofibromin and its implications - Wikidata - wikimedia - TriplyDB

Structural analysis of the GAP-related domain from neurofibromin and its implications

Structural analysis of the GAP-related domain from neurofibromin and its implications

http://www.wikidata.org/entity/Q33889193

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Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin Crystal structure of the GTPase-activating protein-related domain from IQGAP1 Regulation of small GTPases by GEFs, GAPs, and GDIs Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins Structure of the ExoS GTPase activating domain Structure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules.Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration Crystal structure of a truncated urease accessory protein UreF from Helicobacter pylori Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin Tfs1p, a member of the PEBP family, inhibits the Ira2p but not the Ira1p Ras GTPase-activating protein in Saccharomyces cerevisiae Neurofibromatosis type 1 alternative splicing is a key regulator of Ras signaling in neurons The semaphorin 3A receptor may directly regulate the activity of small GTPases.Ca2+-dependent GTPase, extra-large G protein 2 (XLG2), promotes activation of DNA-binding protein related to vernalization 1 (RTV1), leading to activation of floral integrator genes and early flowering in Arabidopsis.NF1 gene mutations represent the major molecular event underlying neurofibromatosis-Noonan syndrome.Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations Genetic effects on human cognition: lessons from the study of mental retardation syndromes A Homogenous Bioluminescent System for Measuring GTPase, GTPase Activating Protein, and Guanine Nucleotide Exchange Factor Activities.Structural mechanisms of plexin signaling Direct evidence that a conserved arginine in RuvB AAA+ ATPase acts as an allosteric effector for the ATPase activity of the adjacent subunit in a hexamer.A method to determine 18 O kinetic isotope effects in the hydrolysis of nucleotide triphosphates.Interaction between a Domain of the Negative Regulator of the Ras-ERK Pathway, SPRED1 Protein, and the GTPase-activating Protein-related Domain of Neurofibromin Is Implicated in Legius Syndrome and Neurofibromatosis Type 1.Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution.A novel stem loop control element-dependent UGA read-through system without translational selenocysteine incorporation in Drosophila.The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation Transition state structures and the roles of catalytic residues in GAP-facilitated GTPase of Ras as elucidated by (18)O kinetic isotope effects.Genetic basis of cognitive disability.Connections between constitutional mismatch repair deficiency syndrome and neurofibromatosis type 1.Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but points to a functional domain upstream of the GAP-related domain.Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase Neurofibromin GTPase-activating protein-related domains restore normal growth in Nf1-/- cells.The Structural Basis for Cdc42-Induced Dimerization of IQGAPs.The spectrum of NF1 mutations in Korean patients with neurofibromatosis type 1.Screening in silico predicted remotely acting NF1 gene regulatory elements for mutations in patients with neurofibromatosis type 1.NF1 modulates the effects of Ras oncogenes: evidence of other NF1 function besides its GAP activity.GTPase stimulation in shrimp Ras(Q(61)K) with geranylgeranyl pyrophosphate but not mammalian GAP.Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction.Functional analysis of a duplication (p.E63_D69dup) in the switch II region of HRAS: new aspects of the molecular pathogenesis underlying Costello syndrome.Neurofibromin is actively transported to the nucleus.New model for the interaction of IQGAP1 with CDC42 and RAC1.

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Structural analysis of the GAP-related domain from neurofibromin and its implications

http://www.wikidata.org/entity/Q33889193

description

1998 nî lūn-bûn

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1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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1998 թվականի օգոստոսին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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name

Structural analysis of the GAP-related domain from neurofibromin and its implications

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Structural analysis of the GAP-related domain from neurofibromin and its implications

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Structural analysis of the GAP-related domain from neurofibromin and its implications

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Structural analysis of the GAP-related domain from neurofibromin and its implications

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Structural analysis of the GAP-related domain from neurofibromin and its implications

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Structural analysis of the GAP-related domain from neurofibromin and its implications

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The EMBO Journal

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Structural analysis of the GAP-related domain from neurofibromin and its implications

@en

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Ahmadian MR

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Kabsch W

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Scheffzek K

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Schmitz F

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Stege P

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Wiesmüller L

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P2860

Somatic mutations in the neurofibromatosis 1 gene in human tumors

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

Molecular genetics of neurofibromatosis type 1 (NF1)

Identification of neurofibromin mutants that exhibit allele specificity or increased Ras affinity resulting in suppression of activated ras alleles

Improved methods for building protein models in electron density maps and the location of errors in these models

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

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10.1093/EMBOJ/17.15.4313

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15

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17

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13596722

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9687500

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1170765

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