Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. - Wikidata - wikimedia - TriplyDB

Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade.

Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade.

http://www.wikidata.org/entity/Q33890028

about

The caveolin proteins Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy.Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers A functional interaction between sprouty proteins and caveolin-1 Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas Caveolin-1: an essential modulator of cancer cell radio-and chemoresistance Nitric oxide regulates lung carcinoma cell anoikis through inhibition of ubiquitin-proteasomal degradation of caveolin-1 Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis Endothelin-1 activates mesangial cell ERK1/2 via EGF-receptor transactivation and caveolin-1 interaction Hierarchical scaffolding of an ERK1/2 activation pathway Caveolae-associated proteins in cardiomyocytes: caveolin-2 expression and interactions with caveolin-3 Sonic hedgehog ligand partners with caveolin-1 for intracellular transport Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae.The membrane-spanning domains of caveolins-1 and -2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo Caveolin-1 knockout mice show an impaired angiogenic response to exogenous stimuli Phosphoinositide 3-kinase C2β regulates RhoA and the actin cytoskeleton through an interaction with Dbl Hypermethylation of the caveolin-1 gene promoter in prostate cancer.Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases.The tetraspan protein EMP2 regulates expression of caveolin-1.Nerve Growth Factor Signaling from Membrane Microdomains to the Nucleus: Differential Regulation by Caveolins.Caveolin-1 expression in different types of psoriatic lesions: analysis of 66 cases Caveolins, liquid-ordered domains, and signal transduction.Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway.Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts.Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism.Caveolin-1: a tumor-promoting role in human cancer.An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation.Caveolin 1 protein expression in renal cell carcinoma predicts survival.Caveolins and cellular cholesterol balance.Knockdown of caveolin-1 by siRNA inhibits the transformation of mouse hepatoma H22 cells in vitro and in vivo Stimulus-specific activation and actin dependency of distinct, spatially separated ERK1/2 fractions in A7r5 smooth muscle cells.Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition.KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of caveolin-1 in response to cholesterol signaling.Fragile sites-cytogenetic similarity with molecular diversity.The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1.

P2860

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P2860

Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade.

http://www.wikidata.org/entity/Q33890028

description

1998 nî lūn-bûn

@nan

1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

1998年の論文

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1998年論文

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1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

name

Targeted downregulation of cav ...... the p42/44 MAP kinase cascade.

@ast

Targeted downregulation of cav ...... the p42/44 MAP kinase cascade.

@en

type

label

Targeted downregulation of cav ...... the p42/44 MAP kinase cascade.

@ast

Targeted downregulation of cav ...... the p42/44 MAP kinase cascade.

@en

prefLabel

Targeted downregulation of cav ...... the p42/44 MAP kinase cascade.

@ast

Targeted downregulation of cav ...... the p42/44 MAP kinase cascade.

@en

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The EMBO Journal

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Targeted downregulation of cav ...... the p42/44 MAP kinase cascade.

@en

P2093

D Volonte

http://www.w3.org/2001/XMLSchema#string

F Galbiati

http://www.w3.org/2001/XMLSchema#string

G Watanabe

http://www.w3.org/2001/XMLSchema#string

J A Engelman

http://www.w3.org/2001/XMLSchema#string

M P Lisanti

http://www.w3.org/2001/XMLSchema#string

R Burk

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R G Pestell

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P2860

Identification, sequence, and expression of caveolin-2 defines a caveolin gene family

Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer

Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo

VIP21/caveolin is a cholesterol-binding protein

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles

Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis

Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity

Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities

Expression and characterization of recombinant caveolin. Purification by polyhistidine tagging and cholesterol-dependent incorporation into defined lipid membranes

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6633-6648

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22

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232762832

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9822607

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1171009

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