Chemical genomics profiling of environmental chemical modulation of human nuclear receptors. - Wikidata - wikimedia - TriplyDB

Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.

Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.

http://www.wikidata.org/entity/Q33890181

about

The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality Effect of chemical mutagens and carcinogens on gene expression profiles in human TK6 cells Multidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticides Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data Intersection of toxicogenomics and high throughput screening in the Tox21 program: an NIEHS perspective Paradigm shift in toxicity testing and modeling.Ethinyl estradiol and other human pharmaceutical estrogens in the aquatic environment: a review of recent risk assessment data A Data Analysis Pipeline Accounting for Artifacts in Tox21 Quantitative High-Throughput Screening Assays Comparison of Points of Departure for Health Risk Assessment Based on High-Throughput Screening Data.A Quantitative High-Throughput Screening Data Analysis Pipeline for Activity Profiling.Development and Validation of a Computational Model for Androgen Receptor Activity Using weighted entropy to rank chemicals in quantitative high-throughput screening experiments AroER tri-screen is a biologically relevant assay for endocrine disrupting chemicals modulating the activity of aromatase and/or the estrogen receptor.Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway Designing Endocrine Disruption Out of the Next Generation of Chemicals Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach.A three-stage algorithm to make toxicologically relevant activity calls from quantitative high throughput screening data Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells.Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential.Families of nuclear receptors in vertebrate models: characteristic and comparative toxicological perspective Identification of thyroid hormone receptor active compounds using a quantitative high-throughput screening platform.Development of phenotypic and transcriptional biomarkers to evaluate relative activity of potentially estrogenic chemicals in ovariectomized mice Cell-Based High-Throughput Screening for Aromatase Inhibitors in the Tox21 10K Library Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform.Identification of compounds that modulate retinol signaling using a cell-based qHTS assay.Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing.Mapping Proteome-Wide Targets of Environmental Chemicals Using Reactivity-Based Chemoproteomic Platforms Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform.Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals.In vitro bioassays to evaluate complex chemical mixtures in recycled water.Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization.A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor Improving the human hazard characterization of chemicals: a Tox21 update Bisphenol A affects androgen receptor function via multiple mechanisms.Comment on "On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens".Advancing toxicology research using in vivo high throughput toxicology with small fish models.Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals.

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Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.

http://www.wikidata.org/entity/Q33890181

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2011年の論文

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Christopher P Austin

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David J Dix

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Keith A Houck

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Kristine L Witt

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Menghang Xia

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Ming-Hsuang Cho

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Paul Shinn

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Raymond R Tice

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Robert J Kavlock

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Ruili Huang

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P2860

Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome

Molecular basis of agonism and antagonism in the oestrogen receptor

The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Effects of environmental antiandrogens on reproductive development in experimental animals

Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor

Principles for modulation of the nuclear receptor superfamily

Identification of environmental chemicals with estrogenic activity using a combination of in vitro assays

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

Compound cytotoxicity profiling using quantitative high-throughput screening.

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1142-1148

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10.1289/EHP.1002952

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8

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119

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Richard S. Judson

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3237348

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