Sphingolipid synthesis as a target for chemotherapy against malaria parasites.
about
Identification of a family of animal sphingomyelin synthases.Anti-Plasmodium activity of ceramide analogsPlasmodium Rab5b is secreted to the cytoplasmic face of the tubovesicular network in infected red blood cells together with N-acylated adenylate kinase 2.The malaria secretome: from algorithms to essential function in blood stage infectionAn erythrocyte vesicle protein exported by the malaria parasite promotes tubovesicular lipid import from the host cell surfacePlasmodium falciparum phospholipase C hydrolyzing sphingomyelin and lysocholinephospholipids is a possible target for malaria chemotherapyThe Plasmodium berghei translocon of exported proteins reveals spatiotemporal dynamics of tubular extensions.Sphingolipid analogues inhibit development of malaria parasites.Monitoring the uptake of glycosphingolipids in Plasmodium falciparum-infected erythrocytes using both fluorescence microscopy and capillary electrophoresis with laser-induced fluorescence detection.Sphingolipids in parasitic protozoaLimonoid compounds inhibit sphingomyelin biosynthesis by preventing CERT protein-dependent extraction of ceramides from the endoplasmic reticulum.Role of sphingolipids in microbial pathogenesisProtein and lipid trafficking induced in erythrocytes infected by malaria parasites.Vacuolar uptake of host components, and a role for cholesterol and sphingomyelin in malarial infection.Neutral-lipid analysis reveals elevation of acylglycerols and lack of cholesterol esters in Plasmodium falciparum-infected erythrocytes.A sphingolipid inhibitor induces a cytokinesis arrest and blocks stage differentiation in Giardia lambliaChanges in lipid composition during sexual development of the malaria parasite Plasmodium falciparum.Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexansFatty acids from Plasmodium falciparum down-regulate the toxic activity of malaria glycosylphosphatidylinositols.The antifungal Aureobasidin A and an analogue are active against the protozoan parasite Toxoplasma gondii but do not inhibit sphingolipid biosynthesis.Trypanocidal Activity of Long Chain Diamines and Aminoalcohols.Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites.Neutral sphingomyelinase activity dependent on Mg2+ and anionic phospholipids in the intraerythrocytic malaria parasite Plasmodium falciparum.Targeting the malarial plastid via the parasitophorous vacuole.
P2860
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P2860
Sphingolipid synthesis as a target for chemotherapy against malaria parasites.
description
1995 nî lūn-bûn
@nan
1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Sphingolipid synthesis as a target for chemotherapy against malaria parasites.
@ast
Sphingolipid synthesis as a target for chemotherapy against malaria parasites.
@en
type
label
Sphingolipid synthesis as a target for chemotherapy against malaria parasites.
@ast
Sphingolipid synthesis as a target for chemotherapy against malaria parasites.
@en
prefLabel
Sphingolipid synthesis as a target for chemotherapy against malaria parasites.
@ast
Sphingolipid synthesis as a target for chemotherapy against malaria parasites.
@en
P2093
P2860
P356
P1476
Sphingolipid synthesis as a target for chemotherapy against malaria parasites.
@en
P2093
P2860
P304
P356
10.1073/PNAS.92.20.9181
P407
P577
1995-09-01T00:00:00Z