Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging. - Wikidata - wikimedia - TriplyDB

Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging.

Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging.

http://www.wikidata.org/entity/Q33891793

about

Energy Metabolism Plays a Critical Role in Stem Cell Maintenance and Differentiation Changes in Regenerative Capacity through Lifespan Can Metabolic Mechanisms of Stem Cell Maintenance Explain Aging and the Immortal Germline?To breathe or not to breathe: the haematopoietic stem/progenitor cells dilemma Mitophagy in hematopoietic stem cells: the case for exploration Hematopoietic stem cell niche maintenance during homeostasis and regeneration Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer Accumulation of DNA damage in the aged hematopoietic stem cell compartment Mitochondria: in sickness and in health Postnatal development, maturation and aging in the mouse cochlea and their effects on hair cell regeneration.Haematological abnormalities in mitochondrial disorders.Cdc42 and aging of hematopoietic stem cells.Metabolic requirements for the maintenance of self-renewing stem cells.Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background.Stem cell aging: mechanisms, regulators and therapeutic opportunities.Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development.Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice.Stem cells and the impact of ROS signaling.Concise review: hematopoietic stem cell aging and the prospects for rejuvenation Adaptation of leukemia cells to hypoxic condition through switching the energy metabolism or avoiding the oxidative stress Human stem cell aging: do mitochondrial DNA mutations have a causal role?Not so benign haematology: anaemia of the elderly Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells Bcl2 inhibition of mitochondrial DNA repair.Mechanisms linking mtDNA damage and aging.mtDNA Mutagenesis Disrupts Pluripotent Stem Cell Function by Altering Redox Signaling.Dynamic HoxB4-regulatory network during embryonic stem cell differentiation to hematopoietic cells.Accumulation of Mitochondrial DNA Mutations Disrupts Cardiac Progenitor Cell Function and Reduces Survival.Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3.Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome The role of DNA exonucleases in protecting genome stability and their impact on ageing.The Mitochondrial Basis of Aging.Epidermal growth factor regulates hematopoietic regeneration after radiation injury Disruption of Glut1 in Hematopoietic Stem Cells Prevents Myelopoiesis and Enhanced Glucose Flux in Atheromatous Plaques of ApoE(-/-) Mice.Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation Mechanisms that regulate stem cell aging and life span Peroxisome proliferator-activated-γ coactivator-1α-mediated mitochondrial biogenesis is important for hematopoietic recovery in response to stress.REGγ deficiency promotes premature aging via the casein kinase 1 pathway.

P2860

Q26768456-89FCF27B-5BC6-4E37-BF4F-A8BE6482A171 Q26778013-F2A23B11-8CA9-4582-A503-199CC883C257 Q26822838-EC750DB0-397C-4499-BD21-850A732FA583 Q26825809-41446B30-A0DF-4FED-BBC0-5B4200BA2BD7 Q26865108-7ED9A3A7-ABE6-4EEC-A3E9-428A104AC7E5 Q26865273-BDF0F63A-EE84-4150-8FC6-577CA3C8C4F0 Q28384025-D9526A4C-6036-4C88-927C-9145DE982F76 Q29248538-BA4F934B-CAE4-4C23-8707-CCF1685E40EA Q29614825-BAD893B5-AF36-4D6B-A9E6-3DE9CE6D7C09 Q30442295-4E0587CA-7319-48F0-B730-9FD19AFB519B Q33424930-DB540963-8C0A-4137-B822-F5D68CFBABC5 Q33753610-7369BF97-CFB5-4931-9B17-FD229F26B35F Q33893346-BCB87255-20E1-4124-B0F1-257C2508CC4B Q34130756-D5D1AB1F-137D-4D78-9D87-7BDB07F05390 Q34159765-125D4FBF-3C88-41B5-AB3D-1277348F2D01 Q34213867-2419C338-3A46-474F-BBB6-962266CFFCCB Q34589585-986AE4D9-95DF-4796-AE4B-9D370DA3717F Q34722748-02941073-AC7F-43C1-82AC-7516435534D0 Q34802375-8D4767B7-D0D5-4E6B-81DC-750C561AB51F Q34999296-566A19CC-F416-4332-89A2-0ABA08B5C9B8 Q35001363-D0144906-8D48-4E0A-BE38-E5797EF6F277 Q35088910-C733A85A-85F6-479D-A607-0B3B2332FD5F Q35093139-0E48C6BD-81D8-45B9-B99C-5705E44E0353 Q35631773-12E2D736-75E3-414A-AE9D-3A02C988484E Q35684586-97DD98A3-1BA1-4F7B-8141-447AB981914C Q35744299-7FF0293F-F80E-4E5A-92AF-EDC212D89073 Q35868104-42F2ECCD-B884-4718-AE60-B84BE5A6B552 Q35875121-53D86EC9-6764-4AD2-9F25-9B8248A14C17 Q35995253-42659477-4332-49FE-A78B-AA2BAFF66893 Q36065239-0D94F547-6AE6-4606-B3B3-F7FAE96FE436 Q36078562-5B98376D-F66F-4796-BBB0-19CD3066CDEE Q36395604-867E3FB1-1650-40AC-9114-E99731F3ABDC Q36483126-00C79307-BE61-4E4D-A950-AE566F7AA1D1 Q36654160-E4AA45A1-AAD9-4CE5-87FE-4BD76265A1FF Q36674536-C7F4E577-EAC9-43DD-B659-2E13ED5F3D8B Q36776429-6856DFAC-5DF6-48E9-B1BC-65A32E125342 Q36783485-5A9EB56D-5AB5-4689-93EC-70C4622E216A Q36810649-76EC8F8B-6E86-4FC7-912A-34F9D0619048 Q36853131-A8FF7A7A-5823-45E5-8F84-4EC5E30B0567 Q36990873-FC045CEF-A709-420A-9983-17BBBACB1FB6

P2860

Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging.

http://www.wikidata.org/entity/Q33891793

description

2011 nî lūn-bûn

@nan

2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Accumulating mitochondrial DNA ...... physiological stem cell aging.

@ast

Accumulating mitochondrial DNA ...... physiological stem cell aging.

@en

type

label

Accumulating mitochondrial DNA ...... physiological stem cell aging.

@ast

Accumulating mitochondrial DNA ...... physiological stem cell aging.

@en

prefLabel

Accumulating mitochondrial DNA ...... physiological stem cell aging.

@ast

Accumulating mitochondrial DNA ...... physiological stem cell aging.

@en

P1433

Q33891793-A8733C28-FF1E-46B4-B4DA-255C99766424

P1476

Q33891793-133D8722-97D9-45A9-A9D9-E4C771E4DE5F

P2093

Q33891793-10D904CF-07B7-4A2A-A1C7-2EBDDB8D91B5

Q33891793-39C2E7C6-4DCF-4CD9-9EF2-43A51E84E811

Q33891793-3EC7DB7F-3B69-45FA-9D9D-DA43A7BE552F

Q33891793-5CDBBE0D-38B6-4B5F-9AD3-DA1825645A05

Q33891793-6CA3133E-265D-4EEE-A1B5-1E714391BF6D

Q33891793-979DCDA5-AB41-429F-8259-9635BC54EFBA

Q33891793-9B3C0655-F88B-4ED9-A190-49FD105EEC3D

Q33891793-D516FA20-95C2-451A-A11E-035684D32C51

P304

Q33891793-1457FAEC-823B-4D0A-9759-C04411A3C7E6

P31

Q33891793-00BD026B-B323-46CB-BE0D-7EFF1C0A8D10

P356

Q33891793-816AAC95-D72F-44A0-A93E-90E81AB83C49

P407

Q33891793-61DA9951-69E6-40DD-BB1B-E8E629A392D7

P433

Q33891793-64BE8C60-03BE-44F7-B17D-A2067D6AD4DA

P478

Q33891793-7B9F86D5-E356-4A0D-A04A-5623368037F6

P577

Q33891793-6723ADC7-658A-40D5-94E6-B2A52742EDE1

P5875

Q33891793-1674D59D-1F1F-42E9-8424-0687669153B6

P698

Q33891793-71DA2B09-72DB-4DD2-A6FE-89FAD282EF63

P921

Q33891793-2D773B66-442B-41B7-9837-1C573112E2CD

P356

J.STEM.2011.03.009

P1433

P1476

Accumulating mitochondrial DNA ...... physiological stem cell aging.

@en

P2093

Amol Ugale

http://www.w3.org/2001/XMLSchema#string

Cornelis J Pronk

http://www.w3.org/2001/XMLSchema#string

David Bryder

http://www.w3.org/2001/XMLSchema#string

Gerd Sten

http://www.w3.org/2001/XMLSchema#string

Gudmundur L Norddahl

http://www.w3.org/2001/XMLSchema#string

Jens M Nygren

http://www.w3.org/2001/XMLSchema#string

Martin Wahlestedt

http://www.w3.org/2001/XMLSchema#string

Mikael Sigvardsson

http://www.w3.org/2001/XMLSchema#string

P304

499-510

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.STEM.2011.03.009

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

8

http://www.w3.org/2001/XMLSchema#string

P577

2011-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51104763

http://www.w3.org/2001/XMLSchema#string

P698

21549326

http://www.w3.org/2001/XMLSchema#string

P921

mitochondrial DNA