Dynamic diagnosis of familial prion diseases supports the β2-α2 loop as a universal interference target.
about
Structural basis for the protective effect of the human prion protein carrying the dominant-negative E219K polymorphismDNA Polymerase Conformational Dynamics and the Role of Fidelity-Conferring Residues: Insights from Computational SimulationsComplex folding and misfolding effects of deer-specific amino acid substitutions in the β2-α2 loop of murine prion protein.Nanopore analysis of wild-type and mutant prion protein (PrP(C)): single molecule discrimination and PrP(C) kinetics.Structural and dynamic properties of the human prion protein.Molecular dynamics analysis of apolipoprotein-D-lipid hydroperoxide interactions: mechanism for selective oxidation of Met-93.The landscape of the prion protein's structural response to mutation revealed by principal component analysis of multiple NMR ensemblesRequirements for mutant and wild-type prion protein misfolding in vitro.Integrity of helix 2-helix 3 domain of the PrP protein is not mandatory for prion replication.Disruption of the X-loop turn of the prion protein linked to scrapie resistance.Decrypting Prion Protein Conversion into a β-Rich Conformer by Molecular DynamicsStructural plasticity of the cellular prion protein and implications in health and disease.PrP(ST), a soluble, protease resistant and truncated PrP form features in the pathogenesis of a genetic prion disease.Early structural features in mammalian prion conformation conversion.Failure of prion protein oxidative folding guides the formation of toxic transmembrane forms.Epitope scanning indicates structural differences in brain-derived monomeric and aggregated mutant prion proteins related to genetic prion diseases.Detailed computational analysis revealed mutation V210I on PrP induced conformational conversion on β2-α2 loop and α2-α3.Minimotifs dysfunction is pervasive in neurodegenerative disorders
P2860
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P2860
Dynamic diagnosis of familial prion diseases supports the β2-α2 loop as a universal interference target.
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Dynamic diagnosis of familial ...... universal interference target.
@ast
Dynamic diagnosis of familial ...... universal interference target.
@en
type
label
Dynamic diagnosis of familial ...... universal interference target.
@ast
Dynamic diagnosis of familial ...... universal interference target.
@en
prefLabel
Dynamic diagnosis of familial ...... universal interference target.
@ast
Dynamic diagnosis of familial ...... universal interference target.
@en
P2860
P50
P1433
P1476
Dynamic diagnosis of familial ...... universal interference target.
@en
P2860
P304
P356
10.1371/JOURNAL.PONE.0019093
P407
P577
2011-04-28T00:00:00Z