The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation.
about
Monoubiquitylation promotes mitochondrial p53 translocationG9a and Glp methylate lysine 373 in the tumor suppressor p53HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA bindingAcetylation is indispensable for p53 activationMOZ increases p53 acetylation and premature senescence through its complex formation with PMLModulation of p53 function by SET8-mediated methylation at lysine 382Lysine acetylation: codified crosstalk with other posttranslational modificationsMechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer CellsAnother fork in the road--life or death decisions by the tumour suppressor p53Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentrationp53 Acetylation: Regulation and ConsequencesMDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activityHdmx modulates the outcome of p53 activation in human tumor cellsThe C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivoModes of p53 regulationp53 ubiquitination: Mdm2 and beyondEnhanced deacetylation of p53 by the anti-apoptotic protein HSCO in association with histone deacetylase 1.Mouse models of p53 functions.How does SIRT1 affect metabolism, senescence and cancer?Mutant TP53 posttranslational modifications: challenges and opportunities.Posttranslational modification of p53: cooperative integrators of functionThe p53 orchestra: Mdm2 and Mdmx set the tonep53 at a glance.In vivo analysis of p53 tumor suppressor function using genetically engineered mouse modelsThe impact of acetylation and deacetylation on the p53 pathway.p53 post-translational modification: deregulated in tumorigenesisLimiting the power of p53 through the ubiquitin proteasome pathway.Recognition of RNA by the p53 tumor suppressor protein in the yeast three-hybrid system.Making sense of ubiquitin ligases that regulate p53.Crippling p53 activities via knock-in mutations in mouse models.The biology of lysine acetylation integrates transcriptional programming and metabolismNew insights into p53 activationCop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice.Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damageFine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivityJMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation.Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is required for neuronal survival after axonal injury.Regulation of p53 function by lysine methylation.Targeting protein lysine methylation and demethylation in cancers.
P2860
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P2860
The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The C-terminal lysines fine-tu ...... ty control or transactivation.
@ast
The C-terminal lysines fine-tu ...... ty control or transactivation.
@en
type
label
The C-terminal lysines fine-tu ...... ty control or transactivation.
@ast
The C-terminal lysines fine-tu ...... ty control or transactivation.
@en
prefLabel
The C-terminal lysines fine-tu ...... ty control or transactivation.
@ast
The C-terminal lysines fine-tu ...... ty control or transactivation.
@en
P2093
P2860
P356
P1476
The C-terminal lysines fine-tu ...... ty control or transactivation.
@en
P2093
Crystal J Lee
Franck Toledo
Geoffrey M Wahl
Kurt A Krummel
P2860
P304
10188-10193
P356
10.1073/PNAS.0503068102
P407
P577
2005-07-08T00:00:00Z