Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts. - Wikidata - wikimedia - TriplyDB

Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.

Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.

http://www.wikidata.org/entity/Q33908939

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Variant of TREM2 Associated with the Risk of Alzheimer's Disease DAP12 signaling: from immune cells to bone modeling and brain myelination Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features Impaired differentiation of osteoclasts in TREM-2-deficient individuals Genes associated with Alzheimer's disease: an overview and current status Genetics ignite focus on microglial inflammation in Alzheimer's disease Phenotypic Heterogeneity of Monogenic Frontotemporal Dementia TREM2 in CNS homeostasis and neurodegenerative disease Strategic applications of gene expression: from drug discovery/development to bedside Brain innate immunity in the regulation of neuroinflammation: therapeutic strategies by modulating CD200-CD200R interaction involve the cannabinoid system Osteoimmunology: Major and Costimulatory Pathway Expression Associated with Chronic Inflammatory Induced Bone Loss Prenatal activation of microglia induces delayed impairment of glutamatergic synaptic function Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2).Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12 Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12)Microglia: Dynamic Mediators of Synapse Development and Plasticity.Microglia as a critical player in both developmental and late-life CNS pathologies.Reconstructing directed gene regulatory network by only gene expression data Lymphocytes and the Dap12 adaptor are key regulators of osteoclast activation associated with gonadal failure.Pattern of DAP12 expression in leukocytes from both healthy and systemic lupus erythematosus patients.Gain in brain immunity in the oldest-old differentiates cognitively normal from demented individuals Direct induction of ramified microglia-like cells from human monocytes: dynamic microglial dysfunction in Nasu-Hakola disease.Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway.New insights on the role of microglia in synaptic pruning in health and disease TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis.Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis On guard--activating NK cell receptors.DAP12 impacts trafficking and surface stability of killer immunoglobulin-like receptors on natural killer cells NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer.Microglia: unique and common features with other tissue macrophages.Diseases of white matter and schizophrenia-like psychosis.Systemic inflammation and the brain: novel roles of genetic, molecular, and environmental cues as drivers of neurodegeneration.Intracellular signaling by the killer immunoglobulin-like receptors and Ly49.Database for the mutations of the Finnish disease heritage.RNA-Seq analysis implicates dysregulation of the immune system in schizophrenia

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Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.

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2000 nî lūn-bûn

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2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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Bakker AB

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