Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo.
about
Engineering polyketide synthases and nonribosomal peptide synthetases.In Vitro Investigation of Crosstalk between Fatty Acid and Polyketide Synthases in the Andrimid Biosynthetic Assembly Line.Using natural products for drug discovery: the impact of the genomics era.Nonribosomal Peptide Synthesis-Principles and Prospects.Harnessing natural product assembly lines: structure, promiscuity, and engineering.Reinvigorating natural product combinatorial biosynthesis with synthetic biologyDiscovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection.Protein design for pathway engineeringEngineering the substrate specificity of the DhbE adenylation domain by yeast cell surface display.Antimicrobial peptides from marine proteobacteria.Directed evolution: selection of the host organism.Characterization and Engineering of the Adenylation Domain of a NRPS-Like Protein: A Potential Biocatalyst for Aldehyde Generation.Protein engineering towards natural product synthesis and diversification.Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity.Progress challenges and opportunities for the re-engineering of trans-AT polyketide synthases.Genetic manipulation of non-ribosomal peptide synthetases to generate novel bioactive peptide products.Interrupted adenylation domains: unique bifunctional enzymes involved in nonribosomal peptide biosynthesis.Recent advances in combinatorial biosynthesis for drug discoveryProfiling of Microbial Colonies for High-Throughput Engineering of Multistep Enzymatic Reactions via Optically Guided Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry.Recent advances in engineering nonribosomal peptide assembly lines.Biosynthetic engineering of nonribosomal peptide synthetases.Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo.Synthetic fermentation of bioactive non-ribosomal peptides without organisms, enzymes or reagents.Directing evolution: the next revolution in drug discovery?Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights.What are the Limitations of Enzymes in Synthetic Organic Chemistry?Rewriting the Metabolic Blueprint: Advances in Pathway Diversification in Microorganisms.Postsynthetic Domain Assembly with NpuDnaE and SspDnaB Split Inteins.Nonribosomal biosynthesis of backbone-modified peptides.
P2860
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P2860
Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Directed evolution of the nonr ...... andrimid derivatives in vivo.
@ast
Directed evolution of the nonr ...... andrimid derivatives in vivo.
@en
type
label
Directed evolution of the nonr ...... andrimid derivatives in vivo.
@ast
Directed evolution of the nonr ...... andrimid derivatives in vivo.
@en
prefLabel
Directed evolution of the nonr ...... andrimid derivatives in vivo.
@ast
Directed evolution of the nonr ...... andrimid derivatives in vivo.
@en
P2093
P2860
P1476
Directed evolution of the nonr ...... andrimid derivatives in vivo.
@en
P2093
Bradley S Evans
Huimin Zhao
Neil L Kelleher
William W Metcalf
Yunqiu Chen
P2860
P304
P356
10.1016/J.CHEMBIOL.2011.03.008
P577
2011-05-01T00:00:00Z