Structural requirements for differential sensitivity of KCNQ K+ channels to modulation by Ca2+/calmodulin.
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The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interactionIntracellular domains interactions and gated motions of I(KS) potassium channel subunitsKCNQ potassium channels in sensory system and neural circuitsStructure of a Ca2+/CaM:Kv7.4 (KCNQ4) B-Helix Complex Provides Insight into M Current ModulationAKAP150-mediated TRPV1 sensitization is disrupted by calcium/calmodulin.Ca2+/calmodulin disrupts AKAP79/150 interactions with KCNQ (M-Type) K+ channelsDeterminants within the turret and pore-loop domains of KCNQ3 K+ channels governing functional activity.Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.Selective interaction of syntaxin 1A with KCNQ2: possible implications for specific modulation of presynaptic activity.Kv7 channels can function without constitutive calmodulin tetheringPhosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channelKCNE4 juxtamembrane region is required for interaction with calmodulin and for functional suppression of KCNQ1.Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels.Phosphatidic acid modulation of Kv channel voltage sensor function.Combined phosphoinositide and Ca2+ signals mediating receptor specificity toward neuronal Ca2+ channels.A change in configuration of the calmodulin-KCNQ channel complex underlies Ca2+-dependent modulation of KCNQ channel activityCalcium and arrhythmogenesis.Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencing.Activation of vascular KCNQ (Kv7) potassium channels reverses spasmogen-induced constrictor responses in rat basilar artery.KCNQ5/K(v)7.5 potassium channel expression and subcellular localization in primate retinal pigment epithelium and neural retinaKv7.5 is the primary Kv7 subunit expressed in C-fibers.Opposite Effects of the S4-S5 Linker and PIP(2) on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels.Regulation of voltage-gated potassium channels by PI(4,5)P2Structural insights into neuronal K+ channel-calmodulin complexes.Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ ChannelsNGF inhibits M/KCNQ currents and selectively alters neuronal excitability in subsets of sympathetic neurons depending on their M/KCNQ current background.Target-specific PIP(2) signalling: how might it work?Quantitative properties and receptor reserve of the DAG and PKC branch of G(q)-coupled receptor signalingThe C-terminus of Kv7 channels: a multifunctional module.Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications.Potassium channels in peripheral pain pathways: expression, function and therapeutic potential.Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.Conditional deletions of epilepsy-associated KCNQ2 and KCNQ3 channels from cerebral cortex cause differential effects on neuronal excitabilityCytoplasmic domains and voltage-dependent potassium channel gating.A rendezvous with the queen of ion channels: Three decades of ion channel research by David T Yue and his Calcium Signals Laboratory.Differential Regulation of PI(4,5)P2 Sensitivity of Kv7.2 and Kv7.3 Channels by Calmodulin.Competition of calcified calmodulin N lobe and PIP2 to an LQT mutation site in Kv7.1 channel.Phosphatidylinositol 4,5-bisphosphate hydrolysis mediates histamine-induced KCNQ/M current inhibition.Pivoting between calmodulin lobes triggered by calcium in the Kv7.2/calmodulin complex.Restoration of ion channel function in deafness-causing KCNQ4 mutants by synthetic channel openers.
P2860
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P2860
Structural requirements for differential sensitivity of KCNQ K+ channels to modulation by Ca2+/calmodulin.
description
2005 nî lūn-bûn
@nan
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Structural requirements for di ...... modulation by Ca2+/calmodulin.
@ast
Structural requirements for di ...... modulation by Ca2+/calmodulin.
@en
Structural requirements for di ...... modulation by Ca2+/calmodulin.
@en-gb
type
label
Structural requirements for di ...... modulation by Ca2+/calmodulin.
@ast
Structural requirements for di ...... modulation by Ca2+/calmodulin.
@en
Structural requirements for di ...... modulation by Ca2+/calmodulin.
@en-gb
prefLabel
Structural requirements for di ...... modulation by Ca2+/calmodulin.
@ast
Structural requirements for di ...... modulation by Ca2+/calmodulin.
@en
Structural requirements for di ...... modulation by Ca2+/calmodulin.
@en-gb
P2860
P356
P1476
Structural requirements for di ...... modulation by Ca2+/calmodulin.
@en
P2093
Mark S Shapiro
P2860
P304
P356
10.1091/MBC.E04-09-0849
P577
2005-05-18T00:00:00Z