Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection.

Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection.

Item
http://www.wikidata.org/entity/Q33913678
A fluorescence-based reporter for monitoring expression of mycobacterial cytochrome bd in response to antibacterials and during infection.Anaerobic Mycobacterium tuberculosis cell death stems from intracellular acidification mitigated by the DosR regulon.Susceptibility of Mycobacterium tuberculosis cytochrome bd oxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.Combinations of Respiratory Chain Inhibitors Have Enhanced Bactericidal Activity against Mycobacterium tuberculosis.Mycobacterial Membrane Proteins QcrB and AtpE: Roles in Energetics, Antibiotic Targets, and Associated Mechanisms of Resistance.Hit Generation in TB Drug Discovery: From Genome to Granuloma.The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd.Plasticity of Mycobacterium tuberculosis NADH dehydrogenases and their role in virulence.Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery.Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents.Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis
P2860

Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection.

Item
http://www.wikidata.org/entity/Q33913678
description
2017 nî lūn-bûn
@nan
2017 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2017 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2017年の論文
@ja
2017年論文
@yue
2017年論文
@zh-hant
2017年論文
@zh-hk
2017年論文
@zh-mo
2017年論文
@zh-tw
2017年论文
@wuu
name
Exploiting the synthetic letha ...... osis and clear host infection.
@ast
Exploiting the synthetic letha ...... osis and clear host infection.
@en
type
label
Exploiting the synthetic letha ...... osis and clear host infection.
@ast
Exploiting the synthetic letha ...... osis and clear host infection.
@en
prefLabel
Exploiting the synthetic letha ...... osis and clear host infection.
@ast
Exploiting the synthetic letha ...... osis and clear host infection.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932
P356
P1433
P1476
Exploiting the synthetic letha ...... losis and clear host infection
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932