about
Rapamycin and its analogues (rapalogs) for tuberous sclerosis complexFolliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signalingActivity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioningRegulation of mTOR and cell growth in response to energy stress by REDD1.Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organsRegulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complexBiochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activityTumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinaseAbnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2Rapamycin and rapalogs for tuberous sclerosis complexPhosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberinTuberin regulates E-cadherin localization: implications in epithelial-mesenchymal transitionTSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPaseA germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in miceAkt regulates growth by directly phosphorylating Tsc2Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberinSurvey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesionsTuberous sclerosis preclinical studies: timing of treatment, combination of a rapamycin analog (CCI-779) and interferon-gamma, and comparison of rapamycin to CCI-779Topical rapamycin inhibits tuberous sclerosis tumor growth in a nude mouse model.Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancerUltra deep sequencing detects a low rate of mosaic mutations in tuberous sclerosis complex.Interaction between genetic susceptibility and early-life environmental exposure determines tumor-suppressor-gene penetrance.TSC2 epigenetic defect in primary LAM cells. Evidence of an anchorage-independent survival.Mutational and radiographic analysis of pulmonary disease consistent with lymphangioleiomyomatosis and micronodular pneumocyte hyperplasia in women with tuberous sclerosis.Tuberous sclerosis: from tubers to mTOR.Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.The neural crest lineage as a driver of disease heterogeneity in Tuberous Sclerosis Complex and Lymphangioleiomyomatosis.TSC2 deficiency increases PTEN via HIF1alphaPediatric liver tumors and hepatic ontogenesis: common and distinctive pathways.Co2/Erbium:YAG/Dye laser combination: an effective and successful treatment for angiofibromas in tuberous sclerosis.Cytogenetics: a new tool for early diagnosis and prognosis of tuberous sclerosis?The search for allelic variants that cause monogenic disorders or predispose to common, complex polygenic phenotypes.Mutations causing syndromic autism define an axis of synaptic pathophysiology.Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG mouse model of tuberous sclerosis complex.Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase.Mouse models of tuberous sclerosis complex.Renal angiomyolipomas in tuberous sclerosis--rare but potentially life-threatening lesions.Regulation of PI 3-K, PTEN, p53, and mTOR in Malignant and Benign Tumors Deficient in TuberinBenign clear cell "sugar" tumor of the lung in a patient with Birt-Hogg-Dubé syndrome: a case reportMolecular pathogenesis of lymphangioleiomyomatosis: lessons learned from orphans
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Molecular genetic advances in tuberous sclerosis.
@ast
Molecular genetic advances in tuberous sclerosis.
@en
type
label
Molecular genetic advances in tuberous sclerosis.
@ast
Molecular genetic advances in tuberous sclerosis.
@en
prefLabel
Molecular genetic advances in tuberous sclerosis.
@ast
Molecular genetic advances in tuberous sclerosis.
@en
P2093
P356
P1433
P1476
Molecular genetic advances in tuberous sclerosis.
@en
P2093
Cheadle JP
Kwiatkowski DJ
Sampson JR
P2888
P304
P356
10.1007/S004390000348
P577
2000-08-01T00:00:00Z
P6179
1019162646