Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins. - Wikidata - wikimedia - TriplyDB

Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.

Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.

http://www.wikidata.org/entity/Q33924487

about

AIPL1, a protein implicated in Leber's congenital amaurosis, interacts with and aids in processing of farnesylated proteins Ras membrane targeting is essential for glucose signaling but not for viability in yeast Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf Purified yeast protein farnesyltransferase is structurally and functionally similar to its mammalian counterpart.The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins.RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins.Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins.SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes.Mating pheromones of the fission yeast Schizosaccharomyces pombe: purification and structural characterization of M-factor and isolation and analysis of two genes encoding the pheromone A novel membrane-associated metalloprotease, Ste24p, is required for the first step of NH2-terminal processing of the yeast a-factor precursor Cloning and expression of a cDNA encoding the alpha subunit of rat p21ras protein farnesyltransferase Farnesyltransferase--new insights into the zinc-coordination sphere paradigm: evidence for a carboxylate-shift mechanism.Mutant farnesyltransferase beta subunit of Saccharomyces cerevisiae that can substitute for geranylgeranyltransferase type I beta subunit.Ras signaling in yeast.Identification of Ras farnesyltransferase inhibitors by microbial screening.Genes encoding farnesyl cysteine carboxyl methyltransferase in Schizosaccharomyces pombe and Xenopus laevis.Fungal lipopeptide mating pheromones: a model system for the study of protein prenylation Genetic evidence for in vivo cross-specificity of the CaaX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase-I in Saccharomyces cerevisiae Acylation stabilizes a protease-resistant conformation of protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides.Endoproteolytic processing of a farnesylated peptide in vitro.Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity Control of RAS mRNA level by the mevalonate pathway.RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis.A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity.Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid Isoprenyl carboxyl methyltransferase inhibitors: a brief review including recent patents.Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway.Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast.Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe.Nucleotide sequence of the yeast STE14 gene, which encodes farnesylcysteine carboxyl methyltransferase, and demonstration of its essential role in a-factor export.Reconstitution of GTP-binding Sar1 protein function in ER to Golgi transport Characterization of the geranylgeranyl transferase type I from Schizosaccharomyces pombe.Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I.Akr1p-dependent palmitoylation of Yck2p yeast casein kinase 1 is necessary and sufficient for plasma membrane targeting.A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues.The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis.

P2860

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P2860

Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.

http://www.wikidata.org/entity/Q33924487

description

1990 nî lūn-bûn

@nan

1990 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1990 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

1990年の論文

@ja

1990年論文

@yue

1990年論文

@zh-hant

1990年論文

@zh-hk

1990年論文

@zh-mo

1990年論文

@zh-tw

1990年论文

@wuu

name

Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.

@ast

Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.

@en

type

label

Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.

@ast

Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.

@en

prefLabel

Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.

@ast

Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.

@en

P1433

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P2860

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P356

PNAS.87.24.9665

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.

@en

P2093

C C Farnsworth

http://www.w3.org/2001/XMLSchema#string

F Tamanoi

http://www.w3.org/2001/XMLSchema#string

J A Glomset

http://www.w3.org/2001/XMLSchema#string

L E Goodman

http://www.w3.org/2001/XMLSchema#string

M H Gelb

http://www.w3.org/2001/XMLSchema#string

S Powers

http://www.w3.org/2001/XMLSchema#string

S R Judd

http://www.w3.org/2001/XMLSchema#string

P2860

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases

Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins.

Processing and fatty acid acylation of RAS1 and RAS2 proteins in Saccharomyces cerevisiae.

All ras proteins are polyisoprenylated but only some are palmitoylated

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini.

G protein gamma subunits contain a 20-carbon isoprenoid.

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides.

p21ras is modified by a farnesyl isoprenoid.

RAS2 of Saccharomyces cerevisiae is required for gluconeogenic growth and proper response to nutrient limitation

P304

9665-9669

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P31

scholarly article

P356

10.1073/PNAS.87.24.9665

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P407

P433

24

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P478

87

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P577

1990-12-01T00:00:00Z

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P5875

21030731

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P698

2124698

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P921

Saccharomyces cerevisiae

P932

55233

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