Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation.
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The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinaseThe human selenoproteome: recent insights into functions and regulationCellular and molecular basis of deiodinase-regulated thyroid hormone signalingThe Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plateDeubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activationDeiodinases: implications of the local control of thyroid hormone actionScope and limitations of iodothyronine deiodinases in hypothyroidismGuidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacementDifferences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine.Substitution of serine for proline in the active center of type 2 iodothyronine deiodinase substantially alters its in vitro biochemical properties with dithiothreitol but not its function in intact cells.Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues.The rs225017 polymorphism in the 3'UTR of the human DIO2 gene is associated with increased insulin resistanceIL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cellsType 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humansQuantity control of the ErbB3 receptor tyrosine kinase at the endoplasmic reticulumMinireview: cracking the metabolic code for thyroid hormone signalingUbiquitinated deiodinase: not dead yetEndoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis.Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice.Defending plasma T3 is a biological priority.Catalysis leads to posttranslational inactivation of the type 1 deiodinase and alters its conformationPhysiological role and regulation of iodothyronine deiodinases: a 2011 update.The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex.American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models.Type 2 deiodinase at the crossroads of thyroid hormone actionAUF1 and HuR: possible implications of mRNA stability in thyroid function and disorders.Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signalingThyroid hormone and the neuroglia: both source and target.Membrane Protein Quantity Control at the Endoplasmic Reticulum.Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity.The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line.Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis.Cracking the code for thyroid hormone signaling.Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes.
P2860
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P2860
Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation.
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2000 nî lūn-bûn
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2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
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2000年論文
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2000年论文
@wuu
name
Selective proteolysis of human ...... ulation of hormone activation.
@ast
Selective proteolysis of human ...... ulation of hormone activation.
@en
type
label
Selective proteolysis of human ...... ulation of hormone activation.
@ast
Selective proteolysis of human ...... ulation of hormone activation.
@en
prefLabel
Selective proteolysis of human ...... ulation of hormone activation.
@ast
Selective proteolysis of human ...... ulation of hormone activation.
@en
P2093
P356
P1476
Selective proteolysis of human ...... ulation of hormone activation.
@en
P2093
A C Bianco
C Goncalves
J W Harney
P R Larsen
P304
P356
10.1210/ME.14.11.1697
P577
2000-11-01T00:00:00Z