Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.
about
TA205, an anti-talin monoclonal antibody, inhibits integrin-talin interactionDisruption of the integrin alphaLbeta2 transmembrane domain interface by beta2 Thr-686 mutation activates alphaLbeta2 and promotes micro-clustering of the alphaL subunitsThe structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signallingStructure and function of the platelet integrin alphaIIbbeta3Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological SynapseEndocytic trafficking of laminin is controlled by dystroglycan and is disrupted in cancers.Structure of the Integrin IIb Transmembrane SegmentStructure of an integrin IIb 3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activationStructural basis of integrin regulation and signalingTwo stage cadherin kinetics require multiple extracellular domains but not the cytoplasmic region.How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation.Integrin alpha IIb beta 3 in a membrane environment remains the same height after Mn2+ activation when observed by cryoelectron tomography.Integrin alphaIIbbeta3 activation in Chinese hamster ovary cells and platelets increases clustering rather than affinityConsensus motif for integrin transmembrane helix associationL718P mutation in the membrane-proximal cytoplasmic tail of beta 3 promotes abnormal alpha IIb beta 3 clustering and lipid microdomain coalescence, and associates with a thrombasthenia-like phenotypeStructural basis of transmembrane domain interactions in integrin signaling.Intermolecular transmembrane domain interactions activate integrin αIIbβ3.The final steps of integrin activation: the end gameSpecificity for homooligomer versus heterooligomer formation in integrin transmembrane helicesTransmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (review).Tests of integrin transmembrane domain homo-oligomerization during integrin ligand binding and signalingCW-EPR studies revealed different motional properties and oligomeric states of the integrin β1a transmembrane domain in detergent micelles or liposomesGlycine dimerization motif in the N-terminal transmembrane domain of the high density lipoprotein receptor SR-BI required for normal receptor oligomerization and lipid transport.Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helicesMultiscale simulations suggest a mechanism for integrin inside-out activation.Identification of integrin beta subunit mutations that alter affinity for extracellular matrix ligand.Integrin αIIbβ3 transmembrane domain separation mediates bi-directional signaling across the plasma membrane.Reconstruction of integrin activation.Tests of the extension and deadbolt models of integrin activationTalin activates integrins by altering the topology of the β transmembrane domainRequirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling.Integrin structures and conformational signalingThree-Dimensional Structures of Full-Length, Membrane-Embedded Human α(IIb)β(3) Integrin ComplexesLocalized lipid packing of transmembrane domains impedes integrin clustering.Structure and mechanics of integrin-based cell adhesion.Differences in regulation of Drosophila and vertebrate integrin affinity by talinIntegrin modulation and signaling in leukocyte adhesion and migration.Platelet integrins and immunoreceptors.Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activationDirectly Activating the Integrin αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering.
P2860
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P2860
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Disrupting integrin transmembr ...... ty, not valency or clustering.
@ast
Disrupting integrin transmembr ...... ty, not valency or clustering.
@en
type
label
Disrupting integrin transmembr ...... ty, not valency or clustering.
@ast
Disrupting integrin transmembr ...... ty, not valency or clustering.
@en
prefLabel
Disrupting integrin transmembr ...... ty, not valency or clustering.
@ast
Disrupting integrin transmembr ...... ty, not valency or clustering.
@en
P2093
P2860
P356
P1476
Disrupting integrin transmembr ...... ity, not valency or clustering
@en
P2093
Bing-Hao Luo
Junichi Takagi
Timothy A Springer
P2860
P304
P356
10.1073/PNAS.0409440102
P407
P577
2005-02-28T00:00:00Z