Human immunodeficiency virus type 1 tropism for brain microglial cells is determined by a region of the env glycoprotein that also controls macrophage tropism.
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Pathogenesis of human immunodeficiency virus infectionLambda interferon inhibits human immunodeficiency virus type 1 infection of macrophagesIdentification of a domain within the human T-cell leukemia virus type 2 envelope required for syncytium induction and replicationChanges in human immunodeficiency virus type 1 envelope glycoproteins responsible for the pathogenicity of a multiply passaged simian-human immunodeficiency virus (SHIV-HXBc2)V3 recombinants indicate a central role for CCR5 as a coreceptor in tissue infection by human immunodeficiency virus type 1.Human immunodeficiency virus type 1 envelope glycoprotein molecules containing membrane fusion-impairing mutations in the V3 region efficiently undergo soluble CD4-stimulated gp120 release.CD56+ T cells inhibit HIV-1 infection of macrophagesHuman immunodeficiency virus neurotropism: an analysis of viral replication and cytopathicity for divergent strains in monocytes and microglia.Determinants of syncytium formation in microglia by human immunodeficiency virus type 1: role of the V1/V2 domainsIdentification of shared populations of human immunodeficiency virus type 1 infecting microglia and tissue macrophages outside the central nervous system.Human immunodeficiency virus type 1 nef quasispecies in pathological tissuePersistence of multiple maternal genotypes of human immunodeficiency virus type I in infants infected by vertical transmission.Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks.Virus receptors: implications for pathogenesis and the design of antiviral agents.Long-term productive human immunodeficiency virus-1 infection in human infant microgliaEffect of 3'-azido-3'-deoxythymidine on human immunodeficiency virus type 1 replication in human fetal brain macrophages.Growth of macrophage-tropic and primary human immunodeficiency virus type 1 (HIV-1) isolates in a unique CD4+ T-cell clone (PM1): failure to downregulate CD4 and to interfere with cell-line-tropic HIV-1.Cooperative effects of the human immunodeficiency virus type 1 envelope variable loops V1 and V3 in mediating infectivity for T cellsSequences regulating tropism of human immunodeficiency virus type 1 for brain capillary endothelial cells map to a unique region on the viral genome.Infection of primary human microglia and monocyte-derived macrophages with human immunodeficiency virus type 1 isolates: evidence of differential tropismPatterns of HIV-1 evolution in individuals with differing rates of CD4 T cell decline.Demented and nondemented patients with AIDS differ in brain-derived human immunodeficiency virus type 1 envelope sequences.Differential regulation of cellular tropism and sensitivity to soluble CD4 neutralization by the envelope gp120 of human immunodeficiency virus type 1.Spontaneous substitutions in the vicinity of the V3 analog affect cell tropism and pathogenicity of simian immunodeficiency virus.Alteration of V3 loop context within the envelope of human immunodeficiency virus type 1 enhances neutralizationThe "V3" domain is a determinant of simian immunodeficiency virus cell tropism.Genetic differences between blood- and brain-derived viral sequences from human immunodeficiency virus type 1-infected patients: evidence of conserved elements in the V3 region of the envelope protein of brain-derived sequencesTissue-mediated selection of viral variants: correlation between glycoprotein mutation and growth in neuronal cells.Human immunodeficiency virus type 1 infection of the brain.The RRE of human immunodeficiency virus type 1 contributes to cell-type-specific viral tropism.Independent variation and positive selection in env V1 and V2 domains within maternal-infant strains of human immunodeficiency virus type 1 in vivoReplication of a macrophage-tropic strain of human immunodeficiency virus type 1 (HIV-1) in a hybrid cell line, CEMx174, suggests that cellular accessory molecules are required for HIV-1 entry.Molecular mimicry between the human immunodeficiency virus type 1 gp120 V3 loop and human brain proteins.Complete nucleotide sequence, genome organization, and biological properties of human immunodeficiency virus type 1 in vivo: evidence for limited defectiveness and complementation.The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitorsTissue-specific sequence alterations in the human immunodeficiency virus type 1 envelope favoring CCR5 usage contribute to persistence of dual-tropic virus in the brain.Expanded tropism of primary human immunodeficiency virus type 1 R5 strains to CD4(+) T-cell lines determined by the capacity to exploit low concentrations of CCR5.Correlated template-switching events during minus-strand DNA synthesis: a mechanism for high negative interference during retroviral recombination.Human immunodeficiency virus type 1 tropism for T-lymphoid cell lines: role of the V3 loop and C4 envelope determinants.
P2860
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P2860
Human immunodeficiency virus type 1 tropism for brain microglial cells is determined by a region of the env glycoprotein that also controls macrophage tropism.
description
1992 nî lūn-bûn
@nan
1992 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Human immunodeficiency virus t ...... o controls macrophage tropism.
@ast
Human immunodeficiency virus t ...... o controls macrophage tropism.
@en
type
label
Human immunodeficiency virus t ...... o controls macrophage tropism.
@ast
Human immunodeficiency virus t ...... o controls macrophage tropism.
@en
prefLabel
Human immunodeficiency virus t ...... o controls macrophage tropism.
@ast
Human immunodeficiency virus t ...... o controls macrophage tropism.
@en
P2093
P2860
P1433
P1476
Human immunodeficiency virus t ...... o controls macrophage tropism.
@en
P2093
Dubois-Dalcq M
O'Brien WA
Sharpless NE
P2860
P304
P407
P577
1992-04-01T00:00:00Z