Atomic basis of CRM1-cargo recognition, release and inhibition
about
Molecular Characterization and Functional Analysis of Annulate Lamellae Pore Complexes in Nuclear Transport in Mammalian Cells.Phase IB Study of Selinexor, a First-in-Class Inhibitor of Nuclear Export, in Patients With Advanced Refractory Bone or Soft Tissue Sarcoma.Nucleo-cytoplasmic transport as a therapeutic target of cancerLocNES: a computational tool for locating classical NESs in CRM1 cargo proteins.Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant TransportNovel reversible selective inhibitor of CRM1 for targeted therapy in ovarian cancerThe Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells.Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation.Structural determinants of nuclear export signal orientation in binding to exportin CRM1.CRM1/XPO1 is associated with clinical outcome in glioma and represents a therapeutic target by perturbing multiple core pathways.Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agents.Selective inhibitors of nuclear export (SINE) in hematological malignancies.Mechanisms Regulating Protein Localization.Breakthrough therapies in B-cell non-Hodgkin lymphoma.Tubby family proteins are adapters for ciliary trafficking of integral membrane proteinsAnti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone.A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia.CRM1 Inhibitors for Antiviral Therapy.A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K.Structural snapshot of cytoplasmic pre-60S ribosomal particles bound by Nmd3, Lsg1, Tif6 and Reh1.Karyopherin-β2 Recognition of a PY-NLS Variant that Lacks the Proline-Tyrosine Motif.XPO1 target occupancy measurements confirm the selinexor recommended phase 2 dose.Verdinexor Targeting of CRM1 is a Promising Therapeutic Approach against RSV and Influenza Viruses.Karyopherins in cancer.Caffeic acid phenethyl ester (CAPE) revisited: Covalent modulation of XPO1/CRM1 activities and implication for its mechanism of action.Nuclear export of ubiquitinated proteins via the UBIN-POST system.Mapping regions in Ste5 that support Msn5-dependent and -independent nuclear export.Exportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore.
P2860
Q30362076-0A02C760-7EB2-42DE-A383-6F09FBDC9B41Q33434141-5ECDF48E-C1B1-465C-8ED1-6DD39CECC21CQ34452108-C8827628-7A30-4E81-9FF3-298E006A0478Q35541125-B4D51400-F08E-4C99-8566-2D6F7A733D59Q35668674-C8703F7B-1CBD-4116-8165-53BC91B65DA4Q35732942-437702BB-ABDC-4EE9-BBB6-6269E11DF665Q35823090-3EE8BCFB-E2D0-47E8-A995-0C2C1CE8D02EQ35910495-A8BF884E-5FA8-4B2F-AE30-F3BC259E6674Q36098844-0681EF3B-6831-4ED7-81FF-821DD8B9B6C5Q36132392-E1BF0D61-1555-4673-A267-C157D30C7335Q37330941-73BD51C7-5252-4C89-B3AA-942743C4A578Q38260357-7F6EE6B3-0B16-43AA-890D-2895B5C77D58Q38368605-B945554A-C360-4374-98FF-ED724FF6B0F4Q38546818-63EAA5DE-FE00-4E8F-AB45-3600B07E03FDQ38708600-E7E7769A-E560-4ED8-BE45-B124228DAA82Q38718216-EB38DD09-02C5-480A-AAC6-FC1DDA78E6DEQ38738390-656B30E4-15C1-4BBC-8706-137CD962D8B2Q38881093-1F7E258B-E9E3-4D4E-B754-70577AAD4763Q39431526-92B6561A-D276-49F0-8788-5F2EFD06E5B3Q39677170-18A9FAA2-8EBA-4720-B387-14AFE94B5C1DQ41382245-40FE8CDC-668D-4F26-8281-DF8A1680719FQ42386471-1ECB3CAA-DBA1-46A9-8F6D-069C94D6BF9BQ47113773-61710167-04BC-4567-8839-EF22249EC16EQ47549703-E8123CF0-2ACE-466A-B8B6-B699F3F40CD5Q50134836-36FF57E7-90BA-45C7-8C6F-D0123368903BQ51318022-2BFF8020-D13D-4824-9466-950CF6DDD65DQ52318700-8919C240-9A5B-4BD7-A949-25AD519CDCB5Q53190949-5E812E36-0EF3-47C9-9820-59F1D4A9F4AEQ55412292-9480845C-9634-4B4F-B022-4BAD9E9FF106
P2860
Atomic basis of CRM1-cargo recognition, release and inhibition
description
2014 nî lūn-bûn
@nan
2014 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մարտին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Atomic basis of CRM1-cargo recognition, release and inhibition
@ast
Atomic basis of CRM1-cargo recognition, release and inhibition
@en
type
label
Atomic basis of CRM1-cargo recognition, release and inhibition
@ast
Atomic basis of CRM1-cargo recognition, release and inhibition
@en
prefLabel
Atomic basis of CRM1-cargo recognition, release and inhibition
@ast
Atomic basis of CRM1-cargo recognition, release and inhibition
@en
P2860
P1476
Atomic basis of CRM1-cargo recognition, release and inhibition
@en
P2093
Yuh Min Chook
P2860
P356
10.1016/J.SEMCANCER.2014.03.002
P577
2014-03-12T00:00:00Z