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Genome wide association study identifies KCNMA1 contributing to human obesity

Genome wide association study identifies KCNMA1 contributing to human obesity

http://www.wikidata.org/entity/Q33943947

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Beyond the fourth wave of genome-wide obesity association studies BK channels: multiple sensors, one activation gate MaxiK channel and cell signalling Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals Probabilistic models of genetic variation in structured populations applied to global human studies Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity Detecting Genomic Signatures of Natural Selection with Principal Component Analysis: Application to the 1000 Genomes Data Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity.Hypothalamic gene transfer of BDNF inhibits breast cancer progression and metastasis in middle age obese mice Modelling BMI trajectories in children for genetic association studies Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat.IGF2, LEPR, POMC, PPARG, and PPARGC1 gene variants are associated with obesity-related risk phenotypes in Brazilian children and adolescents Exome sequencing followed by genotyping suggests SYPL2 as a susceptibility gene for morbid obesity.Susceptibility variants for obesity and colorectal cancer risk: the multiethnic cohort and PAGE studies.Identification of shared genetic susceptibility locus for coronary artery disease, type 2 diabetes and obesity: a meta-analysis of genome-wide studies.Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium Transduction of voltage and Ca2+ signals by Slo1 BK channels.Investigating causality in associations between smoking initiation and schizophrenia using Mendelian randomization.Survival and growth of C57BL/6J mice lacking the BK channel, Kcnma1: lower adult body weight occurs together with higher body fat.Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond.S-acylation dependent post-translational cross-talk regulates large conductance calcium- and voltage- activated potassium (BK) channels.Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity.Regulation of large conductance calcium- and voltage-activated potassium (BK) channels by S-palmitoylation.Gene and environment interaction: Is the differential susceptibility hypothesis relevant for obesity?Multi-variant study of obesity risk genes in African Americans: The Jackson Heart Study.Genetic risk clustering increases children's body weight at 2 years of age - the STEPS Study.Allosteric-activation mechanism of BK channel gating ring triggered by calcium ions.Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity.KCNMA1, a pore-forming α-subunit of BK channels, regulates insulin signalling in mature adipocytes.Fatty Acids, Obesity and Insulin Resistance.Waist circumference to assess reversal of insulin resistance following weight reduction after bariatric surgery: cohort and cross-sectional studies.The adipokine tartrate-resistant acid phosphatase 5a in serum correlates to adipose tissue expansion in obesity.Epigenome-wide methylation differences in a group of lean and obese women - A HUNT Study Genetics of Severe Obesity

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P2860

Genome wide association study identifies KCNMA1 contributing to human obesity

http://www.wikidata.org/entity/Q33943947

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2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Genome wide association study identifies KCNMA1 contributing to human obesity

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Genome wide association study identifies KCNMA1 contributing to human obesity

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Genome wide association study identifies KCNMA1 contributing to human obesity

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Genome wide association study identifies KCNMA1 contributing to human obesity

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Genome wide association study identifies KCNMA1 contributing to human obesity

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Genome wide association study identifies KCNMA1 contributing to human obesity

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BMC Medical Genomics

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Genome wide association study identifies KCNMA1 contributing to human obesity

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P2093

Beatrice Dubern

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David Brodin

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Ferdinand van't Hooft

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Hong Jiao

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Johan Hoffstedt

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Karine Clement

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Peter Arner

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Tomas Axelsson

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P2860

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Large, rare chromosomal deletions associated with severe early-onset obesity

Common variants near MC4R are associated with fat mass, weight and risk of obesity

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

PLINK: a tool set for whole-genome association and population-based linkage analyses

Inactivation of the Fto gene protects from obesity

Genetic and hereditary aspects of childhood obesity

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

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51

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10.1186/1755-8794-4-51

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4

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Karin Dahlman-Wright

Oluf Borbye Pedersen

Johannes Hebebrand

Sébastien Czernichow

Thorkild I A Sørensen

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2011-06-28T00:00:00Z

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51252545

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21708048

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genome-wide association study

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3148553

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